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Association of menstrual cycle and postoperative quality of recovery in premenopausal women: a prospective cohort study

BACKGROUND: Women have poorer quality of postoperative recovery from general anaesthesia than men. This persists for at least 3 days postoperatively, and is more pronounced in premenopausal women. Studies of menstrual cycle effects on pain or postoperative nausea and vomiting report conflicting resu...

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Autores principales: Tan, Nicole L.T., Lee, Sze Wey, Zaloumis, Sophie, Lamb, Karen E., Dawson, Dianne, Teede, Helena J., Myles, Paul S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10430848/
https://www.ncbi.nlm.nih.gov/pubmed/37588793
http://dx.doi.org/10.1016/j.bjao.2022.100102
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author Tan, Nicole L.T.
Lee, Sze Wey
Zaloumis, Sophie
Lamb, Karen E.
Dawson, Dianne
Teede, Helena J.
Myles, Paul S.
author_facet Tan, Nicole L.T.
Lee, Sze Wey
Zaloumis, Sophie
Lamb, Karen E.
Dawson, Dianne
Teede, Helena J.
Myles, Paul S.
author_sort Tan, Nicole L.T.
collection PubMed
description BACKGROUND: Women have poorer quality of postoperative recovery from general anaesthesia than men. This persists for at least 3 days postoperatively, and is more pronounced in premenopausal women. Studies of menstrual cycle effects on pain or postoperative nausea and vomiting report conflicting results. Our aim was to determine whether menstrual cycle phase is associated with quality of recovery after surgery in premenopausal women. METHODS: Eligible women aged 18–45 yr undergoing wisdom teeth extraction or laparoscopic cholecystectomy under general anaesthesia with volatile agents were recruited from Epworth HealthCare Richmond in Melbourne, Australia from 2019 to 2021. Menstrual history and progesterone levels were used to determine cycle phase (luteal or non-luteal). Linear mixed and generalised linear regression models were fitted to examine differences in Quality of Recovery-15 (QoR-15) score on postoperative days 1 (primary outcome) and 3, and secondary outcomes (pain, analgesic effectiveness, postoperative nausea and vomiting, prolonged hospital admission), between groups, adjusting for confounders. RESULTS: A total of 177 women were recruited (74 luteal, 103 non-luteal). Six (3%) underwent laparoscopic cholecystectomy. Estimated mean differences (95% confidence interval; P-value) in adjusted QoR-15 scores between luteal and non-luteal groups were –0.05 (–5.86 to 5.76; P=0.986) and 1.40 (–4.41 to 7.21; P=0.636) on postoperative days 1 and 3, respectively. Secondary outcomes were not different between groups. CONCLUSIONS: There was no significant difference in postoperative QoR-15 score or other outcomes between women in the luteal and non-luteal phases of their cycle. Women can be reassured that cycle phase does not impact postoperative quality of recovery when undergoing minor surgery under general anaesthesia. CLINICAL TRIAL REGISTRATION: ACTRN12618000240246.
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spelling pubmed-104308482023-08-16 Association of menstrual cycle and postoperative quality of recovery in premenopausal women: a prospective cohort study Tan, Nicole L.T. Lee, Sze Wey Zaloumis, Sophie Lamb, Karen E. Dawson, Dianne Teede, Helena J. Myles, Paul S. BJA Open Original Research Article BACKGROUND: Women have poorer quality of postoperative recovery from general anaesthesia than men. This persists for at least 3 days postoperatively, and is more pronounced in premenopausal women. Studies of menstrual cycle effects on pain or postoperative nausea and vomiting report conflicting results. Our aim was to determine whether menstrual cycle phase is associated with quality of recovery after surgery in premenopausal women. METHODS: Eligible women aged 18–45 yr undergoing wisdom teeth extraction or laparoscopic cholecystectomy under general anaesthesia with volatile agents were recruited from Epworth HealthCare Richmond in Melbourne, Australia from 2019 to 2021. Menstrual history and progesterone levels were used to determine cycle phase (luteal or non-luteal). Linear mixed and generalised linear regression models were fitted to examine differences in Quality of Recovery-15 (QoR-15) score on postoperative days 1 (primary outcome) and 3, and secondary outcomes (pain, analgesic effectiveness, postoperative nausea and vomiting, prolonged hospital admission), between groups, adjusting for confounders. RESULTS: A total of 177 women were recruited (74 luteal, 103 non-luteal). Six (3%) underwent laparoscopic cholecystectomy. Estimated mean differences (95% confidence interval; P-value) in adjusted QoR-15 scores between luteal and non-luteal groups were –0.05 (–5.86 to 5.76; P=0.986) and 1.40 (–4.41 to 7.21; P=0.636) on postoperative days 1 and 3, respectively. Secondary outcomes were not different between groups. CONCLUSIONS: There was no significant difference in postoperative QoR-15 score or other outcomes between women in the luteal and non-luteal phases of their cycle. Women can be reassured that cycle phase does not impact postoperative quality of recovery when undergoing minor surgery under general anaesthesia. CLINICAL TRIAL REGISTRATION: ACTRN12618000240246. Elsevier 2022-10-31 /pmc/articles/PMC10430848/ /pubmed/37588793 http://dx.doi.org/10.1016/j.bjao.2022.100102 Text en © 2022 The Author(s) https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Original Research Article
Tan, Nicole L.T.
Lee, Sze Wey
Zaloumis, Sophie
Lamb, Karen E.
Dawson, Dianne
Teede, Helena J.
Myles, Paul S.
Association of menstrual cycle and postoperative quality of recovery in premenopausal women: a prospective cohort study
title Association of menstrual cycle and postoperative quality of recovery in premenopausal women: a prospective cohort study
title_full Association of menstrual cycle and postoperative quality of recovery in premenopausal women: a prospective cohort study
title_fullStr Association of menstrual cycle and postoperative quality of recovery in premenopausal women: a prospective cohort study
title_full_unstemmed Association of menstrual cycle and postoperative quality of recovery in premenopausal women: a prospective cohort study
title_short Association of menstrual cycle and postoperative quality of recovery in premenopausal women: a prospective cohort study
title_sort association of menstrual cycle and postoperative quality of recovery in premenopausal women: a prospective cohort study
topic Original Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10430848/
https://www.ncbi.nlm.nih.gov/pubmed/37588793
http://dx.doi.org/10.1016/j.bjao.2022.100102
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