Cargando…

Low-intensity pulsed ultrasound in obstetrics and gynecology: advances in clinical application and research progress

In the past decade, research on ultrasound therapy in obstetrics and gynecology has rapidly developed. Currently, high-intensity ultrasound has been widely used in clinical practice, while low-intensity ultrasound has gradually emerged as a new trend of transitioning from pre-clinical research to cl...

Descripción completa

Detalles Bibliográficos
Autores principales: Ji, Xiaoyu, Duan, Hua, Wang, Sha, Chang, Yanan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10431596/
https://www.ncbi.nlm.nih.gov/pubmed/37593351
http://dx.doi.org/10.3389/fendo.2023.1233187
_version_ 1785091238544801792
author Ji, Xiaoyu
Duan, Hua
Wang, Sha
Chang, Yanan
author_facet Ji, Xiaoyu
Duan, Hua
Wang, Sha
Chang, Yanan
author_sort Ji, Xiaoyu
collection PubMed
description In the past decade, research on ultrasound therapy in obstetrics and gynecology has rapidly developed. Currently, high-intensity ultrasound has been widely used in clinical practice, while low-intensity ultrasound has gradually emerged as a new trend of transitioning from pre-clinical research to clinical applications. Low-intensity pulsed ultrasound (LIPUS), characterized by a non-invasive low-intensity pulse wave stimulation method, employs its non-thermal effects to achieve safe, economical, and convenient therapeutic outcomes. LIPUS converts into biochemical signals within cells through pathways such as cavitation, acoustic flow, and mechanical stimulation, regulating molecular biological mechanisms and exerting various biological effects. The molecular biology mechanisms underlying the application of LIPUS in obstetrics and gynecology mainly include signaling pathways, key gene expression, angiogenesis, inflammation inhibition, and stem cell differentiation. LIPUS plays a positive role in promoting soft tissue regeneration, bone regeneration, nerve regulation, and changes in cell membrane permeability. LIPUS can improve the treatment benefit of premature ovarian failure, pelvic floor dysfunction, nerve damage caused by intrauterine growth restriction, ovariectomized osteoporosis, and incomplete uterine involution through the above biological effects, and it also has application value in the adjuvant treatment of malignant tumors such as ovarian cancer and cervical cancer. This study outlines the biological mechanisms and applications of LIPUS in treating various obstetric and gynecologic diseases, aiming to promote its precise application and provide a theoretical basis for its use in the field.
format Online
Article
Text
id pubmed-10431596
institution National Center for Biotechnology Information
language English
publishDate 2023
publisher Frontiers Media S.A.
record_format MEDLINE/PubMed
spelling pubmed-104315962023-08-17 Low-intensity pulsed ultrasound in obstetrics and gynecology: advances in clinical application and research progress Ji, Xiaoyu Duan, Hua Wang, Sha Chang, Yanan Front Endocrinol (Lausanne) Endocrinology In the past decade, research on ultrasound therapy in obstetrics and gynecology has rapidly developed. Currently, high-intensity ultrasound has been widely used in clinical practice, while low-intensity ultrasound has gradually emerged as a new trend of transitioning from pre-clinical research to clinical applications. Low-intensity pulsed ultrasound (LIPUS), characterized by a non-invasive low-intensity pulse wave stimulation method, employs its non-thermal effects to achieve safe, economical, and convenient therapeutic outcomes. LIPUS converts into biochemical signals within cells through pathways such as cavitation, acoustic flow, and mechanical stimulation, regulating molecular biological mechanisms and exerting various biological effects. The molecular biology mechanisms underlying the application of LIPUS in obstetrics and gynecology mainly include signaling pathways, key gene expression, angiogenesis, inflammation inhibition, and stem cell differentiation. LIPUS plays a positive role in promoting soft tissue regeneration, bone regeneration, nerve regulation, and changes in cell membrane permeability. LIPUS can improve the treatment benefit of premature ovarian failure, pelvic floor dysfunction, nerve damage caused by intrauterine growth restriction, ovariectomized osteoporosis, and incomplete uterine involution through the above biological effects, and it also has application value in the adjuvant treatment of malignant tumors such as ovarian cancer and cervical cancer. This study outlines the biological mechanisms and applications of LIPUS in treating various obstetric and gynecologic diseases, aiming to promote its precise application and provide a theoretical basis for its use in the field. Frontiers Media S.A. 2023-07-31 /pmc/articles/PMC10431596/ /pubmed/37593351 http://dx.doi.org/10.3389/fendo.2023.1233187 Text en Copyright © 2023 Ji, Duan, Wang and Chang https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Endocrinology
Ji, Xiaoyu
Duan, Hua
Wang, Sha
Chang, Yanan
Low-intensity pulsed ultrasound in obstetrics and gynecology: advances in clinical application and research progress
title Low-intensity pulsed ultrasound in obstetrics and gynecology: advances in clinical application and research progress
title_full Low-intensity pulsed ultrasound in obstetrics and gynecology: advances in clinical application and research progress
title_fullStr Low-intensity pulsed ultrasound in obstetrics and gynecology: advances in clinical application and research progress
title_full_unstemmed Low-intensity pulsed ultrasound in obstetrics and gynecology: advances in clinical application and research progress
title_short Low-intensity pulsed ultrasound in obstetrics and gynecology: advances in clinical application and research progress
title_sort low-intensity pulsed ultrasound in obstetrics and gynecology: advances in clinical application and research progress
topic Endocrinology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10431596/
https://www.ncbi.nlm.nih.gov/pubmed/37593351
http://dx.doi.org/10.3389/fendo.2023.1233187
work_keys_str_mv AT jixiaoyu lowintensitypulsedultrasoundinobstetricsandgynecologyadvancesinclinicalapplicationandresearchprogress
AT duanhua lowintensitypulsedultrasoundinobstetricsandgynecologyadvancesinclinicalapplicationandresearchprogress
AT wangsha lowintensitypulsedultrasoundinobstetricsandgynecologyadvancesinclinicalapplicationandresearchprogress
AT changyanan lowintensitypulsedultrasoundinobstetricsandgynecologyadvancesinclinicalapplicationandresearchprogress