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Ketogenic diet ameliorates attention deficit hyperactivity disorder in rats via regulating gut microbiota

Attention deficit hyperactivity disorder (ADHD) is a common mental behavioral disorder in children. Alterations in gut microbiota composition are associated with neurological disorders. We aimed to investigate whether a ketogenic diet (KD) can be an alternative therapy for ADHD by altering the gut m...

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Autores principales: Liu, Yu, Yang, Changhong, Meng, Yingxue, Dang, Yonghui, Yang, Lin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10431618/
https://www.ncbi.nlm.nih.gov/pubmed/37585373
http://dx.doi.org/10.1371/journal.pone.0289133
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author Liu, Yu
Yang, Changhong
Meng, Yingxue
Dang, Yonghui
Yang, Lin
author_facet Liu, Yu
Yang, Changhong
Meng, Yingxue
Dang, Yonghui
Yang, Lin
author_sort Liu, Yu
collection PubMed
description Attention deficit hyperactivity disorder (ADHD) is a common mental behavioral disorder in children. Alterations in gut microbiota composition are associated with neurological disorders. We aimed to investigate whether a ketogenic diet (KD) can be an alternative therapy for ADHD by altering the gut microbiota. Male spontaneously hypertensive rats (SHR) and Wistar Kyoto (WKY) rats were randomly allocated to the normal diet (ND), methylphenidate (MPH), and KD groups. SHR in groups KD and MPH exhibited a significant increase in behavioral characteristics of ADHD, such as distance moved and immobility time. KD and MPH treatment led to a significant elevation in concentrations of 5-HT, AC, cAMP, and NE of brain tissue and the expression of DRD1, DAT, PKA, DARPP32, and cAMP at the protein level in WKY rats and SHR. KD and MPH significantly increased the richness and diversity of gut microbiota in SHR. The abundance of Ruminococcus_gauvreauii_group, Bacteroides, Bifidobacterium, and Blautia significantly increased, whereas that of Lactobacillus, Romboutsia, Facklamia, and Turicibacter significantly declined in the KD group compared with the ND group. The gut microbiota in the KD group of SHR mainly participated in amino acid metabolism- and sugar metabolism-related pathways. KD might alleviate behavioral disorders in ADHD by regulating gut microbiota. This study provides novel insights for the use of KD in treating ADHD.
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spelling pubmed-104316182023-08-17 Ketogenic diet ameliorates attention deficit hyperactivity disorder in rats via regulating gut microbiota Liu, Yu Yang, Changhong Meng, Yingxue Dang, Yonghui Yang, Lin PLoS One Research Article Attention deficit hyperactivity disorder (ADHD) is a common mental behavioral disorder in children. Alterations in gut microbiota composition are associated with neurological disorders. We aimed to investigate whether a ketogenic diet (KD) can be an alternative therapy for ADHD by altering the gut microbiota. Male spontaneously hypertensive rats (SHR) and Wistar Kyoto (WKY) rats were randomly allocated to the normal diet (ND), methylphenidate (MPH), and KD groups. SHR in groups KD and MPH exhibited a significant increase in behavioral characteristics of ADHD, such as distance moved and immobility time. KD and MPH treatment led to a significant elevation in concentrations of 5-HT, AC, cAMP, and NE of brain tissue and the expression of DRD1, DAT, PKA, DARPP32, and cAMP at the protein level in WKY rats and SHR. KD and MPH significantly increased the richness and diversity of gut microbiota in SHR. The abundance of Ruminococcus_gauvreauii_group, Bacteroides, Bifidobacterium, and Blautia significantly increased, whereas that of Lactobacillus, Romboutsia, Facklamia, and Turicibacter significantly declined in the KD group compared with the ND group. The gut microbiota in the KD group of SHR mainly participated in amino acid metabolism- and sugar metabolism-related pathways. KD might alleviate behavioral disorders in ADHD by regulating gut microbiota. This study provides novel insights for the use of KD in treating ADHD. Public Library of Science 2023-08-16 /pmc/articles/PMC10431618/ /pubmed/37585373 http://dx.doi.org/10.1371/journal.pone.0289133 Text en © 2023 Liu et al https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Liu, Yu
Yang, Changhong
Meng, Yingxue
Dang, Yonghui
Yang, Lin
Ketogenic diet ameliorates attention deficit hyperactivity disorder in rats via regulating gut microbiota
title Ketogenic diet ameliorates attention deficit hyperactivity disorder in rats via regulating gut microbiota
title_full Ketogenic diet ameliorates attention deficit hyperactivity disorder in rats via regulating gut microbiota
title_fullStr Ketogenic diet ameliorates attention deficit hyperactivity disorder in rats via regulating gut microbiota
title_full_unstemmed Ketogenic diet ameliorates attention deficit hyperactivity disorder in rats via regulating gut microbiota
title_short Ketogenic diet ameliorates attention deficit hyperactivity disorder in rats via regulating gut microbiota
title_sort ketogenic diet ameliorates attention deficit hyperactivity disorder in rats via regulating gut microbiota
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10431618/
https://www.ncbi.nlm.nih.gov/pubmed/37585373
http://dx.doi.org/10.1371/journal.pone.0289133
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