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Cross-species analysis identifies mitochondrial dysregulation as a functional consequence of the schizophrenia-associated 3q29 deletion

The 1.6-megabase deletion at chromosome 3q29 (3q29Del) is the strongest identified genetic risk factor for schizophrenia, but the effects of this variant on neurodevelopment are not well understood. We interrogated the developing neural transcriptome in two experimental model systems with complement...

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Detalles Bibliográficos
Autores principales:	Purcell, Ryan H., Sefik, Esra, Werner, Erica, King, Alexia T., Mosley, Trenell J., Merritt-Garza, Megan E., Chopra, Pankaj, McEachin, Zachary T., Karne, Sridhar, Raj, Nisha, Vaglio, Brandon J., Sullivan, Dylan, Firestein, Bonnie L., Tilahun, Kedamawit, Robinette, Maxine I., Warren, Stephen T., Wen, Zhexing, Faundez, Victor, Sloan, Steven A., Bassell, Gary J., Mulle, Jennifer G.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Association for the Advancement of Science 2023
Materias:	Neuroscience
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10431714/ https://www.ncbi.nlm.nih.gov/pubmed/37585521 http://dx.doi.org/10.1126/sciadv.adh0558

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