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Early molecular layer interneuron hyperactivity triggers Purkinje neuron degeneration in SCA1

Toxic proteinaceous deposits and alterations in excitability and activity levels characterize vulnerable neuronal populations in neurodegenerative diseases. Using in vivo two-photon imaging in behaving spinocerebellar ataxia type 1 (Sca1) mice, wherein Purkinje neurons (PNs) degenerate, we identify...

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Detalles Bibliográficos
Autores principales:	Pilotto, Federica, Douthwaite, Christopher, Diab, Rim, Ye, XiaoQian, Al qassab, Zahraa, Tietje, Christoph, Mounassir, Meriem, Odriozola, Adolfo, Thapa, Aishwarya, Buijsen, Ronald A.M., Lagache, Sophie, Uldry, Anne-Christine, Heller, Manfred, Müller, Stefan, van Roon-Mom, Willeke M.C., Zuber, Benoît, Liebscher, Sabine, Saxena, Smita
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Cell Press 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10431915/ https://www.ncbi.nlm.nih.gov/pubmed/37321222 http://dx.doi.org/10.1016/j.neuron.2023.05.016

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