Cargando…

Sclerostin small-molecule inhibitors promote osteogenesis by activating canonical Wnt and BMP pathways

BACKGROUND: The clinical healing environment after a posterior spinal arthrodesis surgery is one of the most clinically challenging bone-healing environments across all orthopedic interventions due to the absence of a contained space and the need to form de novo bone. Our group has previously report...

Descripción completa

Detalles Bibliográficos
Autores principales:	Sangadala, Sreedhara, Kim, Chi Heon, Fernandes, Lorenzo M, Makkar, Pooja, Beck, George R, Boden, Scott D, Drissi, Hicham, Presciutti, Steven M
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	eLife Sciences Publications, Ltd 2023
Materias:	Cell Biology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10431921/ https://www.ncbi.nlm.nih.gov/pubmed/37560905 http://dx.doi.org/10.7554/eLife.63402

Ejemplares similares

The temporal and spatial expression of sclerostin and Wnt signaling factors during the maturation of posterolateral lumbar spine fusions
por: Rodriguez‐Feo, John, et al.
Publicado: (2020)

FK506 Induces Ligand-Independent Activation of the Bone Morphogenetic Protein Pathway and Osteogenesis
por: Sangadala, Sreedhara, et al.
Publicado: (2019)

Correction: Sangadala, S. et al. FK506 Induces Ligand-Independent Activation of the Bone Morphogenetic Protein Pathway and Osteogenesis. Int. J. Mol. Sci. 2019, 20, 1900
por: Sangadala, Sreedhara, et al.
Publicado: (2020)

BMP and Beyond: A 25-Year Historical Review of Translational Spine Research at Emory University
por: Presciutti, Steven, et al.
Publicado: (2018)

Canonical Wnt and TGF-β/BMP signaling enhance melanocyte regeneration but suppress invasiveness, migration, and proliferation of melanoma cells
por: Katkat, Esra, et al.
Publicado: (2023)

The Effect of Sclerostin and Monoclonal Sclerostin Antibody Romosozumab on Osteogenesis and Osteoclastogenesis Mediated by Periodontal Ligament Fibroblasts
por: Pigeaud, Karina E., et al.
Publicado: (2023)

Anti-Sclerostin Antibody Inhibits Internalization of Sclerostin and Sclerostin-Mediated Antagonism of Wnt/LRP6 Signaling
por: van Dinther, Maarten, et al.
Publicado: (2013)

A Novel Role for the BMP Antagonist Noggin in Sensitizing Cells to Non-canonical Wnt-5a/Ror2/Disheveled Pathway Activation
por: Bernatik, Ondrej, et al.
Publicado: (2017)

AAV6 as an effective gene delivery vector for prolonged transgene expression in intervertebral disc cells in vivo
por: Kim, Chi Heon, et al.
Publicado: (2020)

Canonical Wnt signalling requires the BMP pathway to inhibit oligodendrocyte maturation
por: Feigenson, Keith, et al.
Publicado: (2011)

BMP3 expression by osteoblast lineage cells is regulated by canonical Wnt signaling
por: Kokabu, Shoichiro, et al.
Publicado: (2017)

Osteocyte TSC1 promotes sclerostin secretion to restrain osteogenesis in mice
por: Liu, Wen, et al.
Publicado: (2019)

Gender-Related Impact of Sclerostin Antibody on Bone in the Osteogenesis Imperfecta Mouse
por: Cardinal, Mickaël, et al.
Publicado: (2021)

Dysregulation of BMP, Wnt, and Insulin Signaling in Fragile X Syndrome
por: Song, Chunzhu, et al.
Publicado: (2022)

Icariin Promotes the Osteogenesis of Bone Marrow Mesenchymal Stem Cells through Regulating Sclerostin and Activating the Wnt/β-Catenin Signaling Pathway
por: Gao, Jianliang, et al.
Publicado: (2021)

Sclerostin: From Molecule to Clinical Biomarker
por: Omran, Ahmed, et al.
Publicado: (2022)

Canonical Wnt signaling induces BMP-4 to specify slow myofibrogenesis of fetal myoblasts
por: Kuroda, Kazuki, et al.
Publicado: (2013)

Sclerostin, Osteocytes, and Wnt Signaling in Pediatric Renal Osteodystrophy
por: Laster, Marciana, et al.
Publicado: (2023)

Effect of sclerostin inactivation in a mouse model of severe dominant osteogenesis imperfecta
por: Marulanda, Juliana, et al.
Publicado: (2023)

Regeneration of Articular Cartilage by Human ESC‐Derived Mesenchymal Progenitors Treated Sequentially with BMP‐2 and Wnt5a
por: Gibson, Jason D., et al.
Publicado: (2016)

Abstract 137: Contribution of the Non-Canonical BMP Receptor Signaling Pathway Osteogenesis on Bioinspired Nanoparticulate Mineralized Collagen Scaffolds
por: Zhou, Qi, et al.
Publicado: (2017)

Non-canonical Wnt signalling modulates the endothelial shear stress flow sensor in vascular remodelling
por: Franco, Claudio A, et al.
Publicado: (2016)

Non-canonical Wnt signaling regulates junctional mechanocoupling during angiogenic collective cell migration
por: Carvalho, Joana R, et al.
Publicado: (2019)

Noncanonical Wnt5a Signaling Suppresses Hippo/TAZ-Mediated Osteogenesis Partly Through the Canonical Wnt Pathway in SCAPs
por: Fu, Yajing, et al.
Publicado: (2022)

TGF-β Prevents Phosphate-Induced Osteogenesis through Inhibition of BMP and Wnt/β-Catenin Pathways
por: Guerrero, Fátima, et al.
Publicado: (2014)

Runx1 is a central regulator of osteogenesis for bone homeostasis by orchestrating BMP and WNT signaling pathways
por: Tang, Chen-Yi, et al.
Publicado: (2021)

Sclerostin is involved in osteogenic transdifferentiation of vascular smooth muscle cells in chronic kidney disease-associated vascular calcification with non-canonical Wnt signaling
por: Xiao, Qiong, et al.
Publicado: (2022)

Sclerostin-Mediated Impaired Osteogenesis by Fibroblast-Like Synoviocytes in the Particle-Induced Osteolysis Model
por: Jagga, Supriya, et al.
Publicado: (2021)

THU455 Sclerostin Inhibitor Use In The Medical Management Of Osteogenesis Imperfecta Type III
por: Lundholm, Michelle Diane, et al.
Publicado: (2023)

Triiodothyronine Potentiates BMP9-Induced Osteogenesis in Mesenchymal Stem Cells Through the Activation of AMPK/p38 Signaling
por: Chen, Xiaoting, et al.
Publicado: (2020)

A Non-canonical Wnt Signature Correlates With Lower Survival in Gastric Cancer
por: Astudillo, Pablo
Publicado: (2021)

The Usher syndrome 1C protein harmonin regulates canonical Wnt signaling
por: Schäfer, Jessica, et al.
Publicado: (2023)

Sclerostin Is an Osteocyte-expressed Negative Regulator of Bone Formation, But Not a Classical BMP Antagonist
por: van Bezooijen, Rutger L., et al.
Publicado: (2004)

Monitoring of canonical BMP and Wnt activities during postnatal stages of mouse first molar root formation
por: WANG, Jia, et al.
Publicado: (2021)

Canonical WNT/β-Catenin Signaling Activated by WNT9b and RSPO2 Cooperation Regulates Facial Morphogenesis in Mice
por: Jin, Yong-Ri, et al.
Publicado: (2020)

Correction: TGF-β Prevents Phosphate-Induced Osteogenesis through Inhibition of BMP and Wnt/β-Catenin Pathways
Publicado: (2014)

Correction: Runx1 is a central regulator of osteogenesis for bone homeostasis by orchestrating BMP and WNT signaling pathways
por: Tang, Chen-Yi, et al.
Publicado: (2022)

Network Analysis Identifies Gene Regulatory Network Indicating the Role of RUNX1 in Human Intervertebral Disc Degeneration
por: Khan, Nazir M., et al.
Publicado: (2020)

Gene Expression Profile and Acute Gene Expression Response to Sclerostin Inhibition in Osteogenesis Imperfecta Bone
por: Surowiec, Rachel K, et al.
Publicado: (2020)

Icaritin promotes the osteogenesis of bone marrow mesenchymal stem cells via the regulation of sclerostin expression
por: Wei, Qiushi, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_bta5jjchtjke9i47nkm88bpni8