Disseminated Kaposi Sarcoma Associated With Cytomegalovirus Proctitis in People Living With Human Immunodeficiency Virus (PLHIV): A Major Diagnostic Dilemma

Kaposi sarcoma (KS) is a vascular tumor of low malignancy. Lesions may vary in shape, color, and size. Angiogenesis, spindle-shaped cells, and inflammatory infiltration are the main histologic features of the condition. Human herpesvirus-8 (HHV-8) infection and immune dysfunction play a key role in...

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Autores principales: Portella, Rodrigo, Ponce, Cesar Cilento, Patzina, Rosely Antunes, Ardengh, Jose C, Calanca, Richard
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cureus 2023
Materias:
Gastroenterology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10431931/
https://www.ncbi.nlm.nih.gov/pubmed/37593320
http://dx.doi.org/10.7759/cureus.42039
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author Portella, Rodrigo
Ponce, Cesar Cilento
Patzina, Rosely Antunes
Ardengh, Jose C
Calanca, Richard
author_facet Portella, Rodrigo
Ponce, Cesar Cilento
Patzina, Rosely Antunes
Ardengh, Jose C
Calanca, Richard
author_sort Portella, Rodrigo
collection PubMed
description Kaposi sarcoma (KS) is a vascular tumor of low malignancy. Lesions may vary in shape, color, and size. Angiogenesis, spindle-shaped cells, and inflammatory infiltration are the main histologic features of the condition. Human herpesvirus-8 (HHV-8) infection and immune dysfunction play a key role in the development of KS. We report a case of a 40-year-old man with disseminated KS (DKS) who underwent an endoscopic examination. Colonoscopy revealed an ulcer in the anal canal. Biopsy and immunohistochemistry (IHC) confirmed the diagnosis of cytomegalovirus (CMV) proctitis, a rare and underreported pathology.
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spelling pubmed-104319312023-08-17 Disseminated Kaposi Sarcoma Associated With Cytomegalovirus Proctitis in People Living With Human Immunodeficiency Virus (PLHIV): A Major Diagnostic Dilemma Portella, Rodrigo Ponce, Cesar Cilento Patzina, Rosely Antunes Ardengh, Jose C Calanca, Richard Cureus Gastroenterology Kaposi sarcoma (KS) is a vascular tumor of low malignancy. Lesions may vary in shape, color, and size. Angiogenesis, spindle-shaped cells, and inflammatory infiltration are the main histologic features of the condition. Human herpesvirus-8 (HHV-8) infection and immune dysfunction play a key role in the development of KS. We report a case of a 40-year-old man with disseminated KS (DKS) who underwent an endoscopic examination. Colonoscopy revealed an ulcer in the anal canal. Biopsy and immunohistochemistry (IHC) confirmed the diagnosis of cytomegalovirus (CMV) proctitis, a rare and underreported pathology. Cureus 2023-07-17 /pmc/articles/PMC10431931/ /pubmed/37593320 http://dx.doi.org/10.7759/cureus.42039 Text en Copyright © 2023, Portella et al. https://creativecommons.org/licenses/by/3.0/This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Gastroenterology
Portella, Rodrigo
Ponce, Cesar Cilento
Patzina, Rosely Antunes
Ardengh, Jose C
Calanca, Richard
Disseminated Kaposi Sarcoma Associated With Cytomegalovirus Proctitis in People Living With Human Immunodeficiency Virus (PLHIV): A Major Diagnostic Dilemma
title Disseminated Kaposi Sarcoma Associated With Cytomegalovirus Proctitis in People Living With Human Immunodeficiency Virus (PLHIV): A Major Diagnostic Dilemma
title_full Disseminated Kaposi Sarcoma Associated With Cytomegalovirus Proctitis in People Living With Human Immunodeficiency Virus (PLHIV): A Major Diagnostic Dilemma
title_fullStr Disseminated Kaposi Sarcoma Associated With Cytomegalovirus Proctitis in People Living With Human Immunodeficiency Virus (PLHIV): A Major Diagnostic Dilemma
title_full_unstemmed Disseminated Kaposi Sarcoma Associated With Cytomegalovirus Proctitis in People Living With Human Immunodeficiency Virus (PLHIV): A Major Diagnostic Dilemma
title_short Disseminated Kaposi Sarcoma Associated With Cytomegalovirus Proctitis in People Living With Human Immunodeficiency Virus (PLHIV): A Major Diagnostic Dilemma
title_sort disseminated kaposi sarcoma associated with cytomegalovirus proctitis in people living with human immunodeficiency virus (plhiv): a major diagnostic dilemma
topic Gastroenterology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10431931/
https://www.ncbi.nlm.nih.gov/pubmed/37593320
http://dx.doi.org/10.7759/cureus.42039
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