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Pathophysiology of encapsulating peritoneal sclerosis: lessons from findings of the past three decades in Japan
Encapsulating peritoneal sclerosis (EPS), a condition with a high mortality rate, is a serious complication of peritoneal dialysis (PD). In Japan, EPS became a central issue in the clinical setting during the mid-90s and the beginning of this century. However, following the introduction of biocompat...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer Nature Singapore
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10432343/ https://www.ncbi.nlm.nih.gov/pubmed/37278945 http://dx.doi.org/10.1007/s10157-023-02360-y |
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author | Nakayama, Masaaki Miyazaki, Masanobu Hamada, Chieko Ito, Yasuhiko Honda, Kazuho |
author_facet | Nakayama, Masaaki Miyazaki, Masanobu Hamada, Chieko Ito, Yasuhiko Honda, Kazuho |
author_sort | Nakayama, Masaaki |
collection | PubMed |
description | Encapsulating peritoneal sclerosis (EPS), a condition with a high mortality rate, is a serious complication of peritoneal dialysis (PD). In Japan, EPS became a central issue in the clinical setting during the mid-90s and the beginning of this century. However, following the introduction of biocompatible neutral PD solutions containing lower levels of glucose degradation products, the incidence and clinical severity of EPS has been greatly lessened. During the past three decades, the etiology of EPS has been elucidated by findings obtained by peritoneal biopsy, laparoscopy, and surgical intervention. Accumulating findings suggest the need for a paradigm change on the nature of EPS pathophysiology; notably, EPS appears not to reflect peritoneal sclerosis per se, but rather the formation of a neo-membrane as a biological reaction to peritoneal injury. This narrative review looks back on the history of EPS in Japan, and discusses EPS pathophysiology, the impact of neutral PD solution on peritoneal protection, and a future novel diagnostic approach, ultra-fine endoscope, for the identification of patients at high risk of EPS. |
format | Online Article Text |
id | pubmed-10432343 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Springer Nature Singapore |
record_format | MEDLINE/PubMed |
spelling | pubmed-104323432023-08-18 Pathophysiology of encapsulating peritoneal sclerosis: lessons from findings of the past three decades in Japan Nakayama, Masaaki Miyazaki, Masanobu Hamada, Chieko Ito, Yasuhiko Honda, Kazuho Clin Exp Nephrol Review Article Encapsulating peritoneal sclerosis (EPS), a condition with a high mortality rate, is a serious complication of peritoneal dialysis (PD). In Japan, EPS became a central issue in the clinical setting during the mid-90s and the beginning of this century. However, following the introduction of biocompatible neutral PD solutions containing lower levels of glucose degradation products, the incidence and clinical severity of EPS has been greatly lessened. During the past three decades, the etiology of EPS has been elucidated by findings obtained by peritoneal biopsy, laparoscopy, and surgical intervention. Accumulating findings suggest the need for a paradigm change on the nature of EPS pathophysiology; notably, EPS appears not to reflect peritoneal sclerosis per se, but rather the formation of a neo-membrane as a biological reaction to peritoneal injury. This narrative review looks back on the history of EPS in Japan, and discusses EPS pathophysiology, the impact of neutral PD solution on peritoneal protection, and a future novel diagnostic approach, ultra-fine endoscope, for the identification of patients at high risk of EPS. Springer Nature Singapore 2023-06-06 2023 /pmc/articles/PMC10432343/ /pubmed/37278945 http://dx.doi.org/10.1007/s10157-023-02360-y Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Review Article Nakayama, Masaaki Miyazaki, Masanobu Hamada, Chieko Ito, Yasuhiko Honda, Kazuho Pathophysiology of encapsulating peritoneal sclerosis: lessons from findings of the past three decades in Japan |
title | Pathophysiology of encapsulating peritoneal sclerosis: lessons from findings of the past three decades in Japan |
title_full | Pathophysiology of encapsulating peritoneal sclerosis: lessons from findings of the past three decades in Japan |
title_fullStr | Pathophysiology of encapsulating peritoneal sclerosis: lessons from findings of the past three decades in Japan |
title_full_unstemmed | Pathophysiology of encapsulating peritoneal sclerosis: lessons from findings of the past three decades in Japan |
title_short | Pathophysiology of encapsulating peritoneal sclerosis: lessons from findings of the past three decades in Japan |
title_sort | pathophysiology of encapsulating peritoneal sclerosis: lessons from findings of the past three decades in japan |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10432343/ https://www.ncbi.nlm.nih.gov/pubmed/37278945 http://dx.doi.org/10.1007/s10157-023-02360-y |
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