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Comparison of the relative impacts of acute consumption of an inulin-enriched diet, milk kefir or a commercial probiotic product on the human gut microbiome and metabolome

It has been established that the human gut microbiota is central to health, and, consequently, there has been a growing desire to positively modulate its composition and/or function through, for example, the use of fermented foods, prebiotics or probiotics. Here, we compare the relative impact of th...

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Autores principales: Walsh, Liam H., Walsh, Aaron M., Garcia-Perez, Isabel, Crispie, Fiona, Costabile, Adele, Ellis, Richard, Finlayson, Jim, Finnegan, Laura A., Claesson, Marcus J., Holmes, Elaine, Cotter, Paul D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10432396/
https://www.ncbi.nlm.nih.gov/pubmed/37587110
http://dx.doi.org/10.1038/s41538-023-00216-z
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author Walsh, Liam H.
Walsh, Aaron M.
Garcia-Perez, Isabel
Crispie, Fiona
Costabile, Adele
Ellis, Richard
Finlayson, Jim
Finnegan, Laura A.
Claesson, Marcus J.
Holmes, Elaine
Cotter, Paul D.
author_facet Walsh, Liam H.
Walsh, Aaron M.
Garcia-Perez, Isabel
Crispie, Fiona
Costabile, Adele
Ellis, Richard
Finlayson, Jim
Finnegan, Laura A.
Claesson, Marcus J.
Holmes, Elaine
Cotter, Paul D.
author_sort Walsh, Liam H.
collection PubMed
description It has been established that the human gut microbiota is central to health, and, consequently, there has been a growing desire to positively modulate its composition and/or function through, for example, the use of fermented foods, prebiotics or probiotics. Here, we compare the relative impact of the daily consumption of an inulin-enriched diet (n = 10), a commercial probiotic-containing fermented milk product (FMP) (n = 10), or a traditional kefir FMP (n = 9), over a 28-day period on the gut microbiome and urine metabolome of healthy human adults. None of the treatments resulted in significant changes to clinical parameters or biomarkers tested. However, shotgun metagenomic analysis revealed that kefir consumption resulted in a significant change in taxonomy, in the form of an increased abundance of the sub-dominant FMP-associated species Lactococcus raffinolactis, which further corresponded to shifts in the urine metabolome. Overall, our results indicated that daily consumption of a single portion of kefir alone resulted in detectable changes to the gut microbiota and metabolome of consumers.
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spelling pubmed-104323962023-08-18 Comparison of the relative impacts of acute consumption of an inulin-enriched diet, milk kefir or a commercial probiotic product on the human gut microbiome and metabolome Walsh, Liam H. Walsh, Aaron M. Garcia-Perez, Isabel Crispie, Fiona Costabile, Adele Ellis, Richard Finlayson, Jim Finnegan, Laura A. Claesson, Marcus J. Holmes, Elaine Cotter, Paul D. NPJ Sci Food Brief Communication It has been established that the human gut microbiota is central to health, and, consequently, there has been a growing desire to positively modulate its composition and/or function through, for example, the use of fermented foods, prebiotics or probiotics. Here, we compare the relative impact of the daily consumption of an inulin-enriched diet (n = 10), a commercial probiotic-containing fermented milk product (FMP) (n = 10), or a traditional kefir FMP (n = 9), over a 28-day period on the gut microbiome and urine metabolome of healthy human adults. None of the treatments resulted in significant changes to clinical parameters or biomarkers tested. However, shotgun metagenomic analysis revealed that kefir consumption resulted in a significant change in taxonomy, in the form of an increased abundance of the sub-dominant FMP-associated species Lactococcus raffinolactis, which further corresponded to shifts in the urine metabolome. Overall, our results indicated that daily consumption of a single portion of kefir alone resulted in detectable changes to the gut microbiota and metabolome of consumers. Nature Publishing Group UK 2023-08-16 /pmc/articles/PMC10432396/ /pubmed/37587110 http://dx.doi.org/10.1038/s41538-023-00216-z Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Brief Communication
Walsh, Liam H.
Walsh, Aaron M.
Garcia-Perez, Isabel
Crispie, Fiona
Costabile, Adele
Ellis, Richard
Finlayson, Jim
Finnegan, Laura A.
Claesson, Marcus J.
Holmes, Elaine
Cotter, Paul D.
Comparison of the relative impacts of acute consumption of an inulin-enriched diet, milk kefir or a commercial probiotic product on the human gut microbiome and metabolome
title Comparison of the relative impacts of acute consumption of an inulin-enriched diet, milk kefir or a commercial probiotic product on the human gut microbiome and metabolome
title_full Comparison of the relative impacts of acute consumption of an inulin-enriched diet, milk kefir or a commercial probiotic product on the human gut microbiome and metabolome
title_fullStr Comparison of the relative impacts of acute consumption of an inulin-enriched diet, milk kefir or a commercial probiotic product on the human gut microbiome and metabolome
title_full_unstemmed Comparison of the relative impacts of acute consumption of an inulin-enriched diet, milk kefir or a commercial probiotic product on the human gut microbiome and metabolome
title_short Comparison of the relative impacts of acute consumption of an inulin-enriched diet, milk kefir or a commercial probiotic product on the human gut microbiome and metabolome
title_sort comparison of the relative impacts of acute consumption of an inulin-enriched diet, milk kefir or a commercial probiotic product on the human gut microbiome and metabolome
topic Brief Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10432396/
https://www.ncbi.nlm.nih.gov/pubmed/37587110
http://dx.doi.org/10.1038/s41538-023-00216-z
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