Integrin β(3) directly inhibits the Gα(13)-p115RhoGEF interaction to regulate G protein signaling and platelet exocytosis

The integrins and G protein-coupled receptors are both fundamental in cell biology. The cross talk between these two, however, is unclear. Here we show that β(3) integrins negatively regulate G protein-coupled signaling by directly inhibiting the Gα(13)-p115RhoGEF interaction. Furthermore, whereas β...

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Detalles Bibliográficos
Autores principales: Zhang, Yaping, Zhao, Xiaojuan, Shen, Bo, Bai, Yanyan, Chang, Claire, Stojanovic, Aleksandra, Wang, Can, Mack, Andrew, Deng, Gary, Skidgel, Randal A., Cheng, Ni, Du, Xiaoping
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10432399/
https://www.ncbi.nlm.nih.gov/pubmed/37587112
http://dx.doi.org/10.1038/s41467-023-40531-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10432399/
https://www.ncbi.nlm.nih.gov/pubmed/37587112
http://dx.doi.org/10.1038/s41467-023-40531-3

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