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Integrin β(3) directly inhibits the Gα(13)-p115RhoGEF interaction to regulate G protein signaling and platelet exocytosis
The integrins and G protein-coupled receptors are both fundamental in cell biology. The cross talk between these two, however, is unclear. Here we show that β(3) integrins negatively regulate G protein-coupled signaling by directly inhibiting the Gα(13)-p115RhoGEF interaction. Furthermore, whereas β...
| Autores principales: | , , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2023
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10432399/ https://www.ncbi.nlm.nih.gov/pubmed/37587112 http://dx.doi.org/10.1038/s41467-023-40531-3 |