Cargando…
The effect of resveratrol, curcumin and quercetin combination on immuno-suppression of tumor microenvironment for breast tumor-bearing mice
Resveratrol, curcumin, and quercetin are the secondary metabolites from medicinal food homology plants, that have been proven their potency in cancer treatment. However, the antitumor effect of a single component is weak. So, herein, we designed an antitumor compound named RCQ composed of resveratro...
Autores principales: | , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2023
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10432483/ https://www.ncbi.nlm.nih.gov/pubmed/37587146 http://dx.doi.org/10.1038/s41598-023-39279-z |
_version_ | 1785091422411554816 |
---|---|
author | Li, Chenchen Xu, Yajun Zhang, Junfeng Zhang, Yuxi He, Wen Ju, Jiale Wu, Yinghua Wang, Yanli |
author_facet | Li, Chenchen Xu, Yajun Zhang, Junfeng Zhang, Yuxi He, Wen Ju, Jiale Wu, Yinghua Wang, Yanli |
author_sort | Li, Chenchen |
collection | PubMed |
description | Resveratrol, curcumin, and quercetin are the secondary metabolites from medicinal food homology plants, that have been proven their potency in cancer treatment. However, the antitumor effect of a single component is weak. So, herein, we designed an antitumor compound named RCQ composed of resveratrol, curcumin, and quercetin. This study examined the effect on tumorigenesis and development of 4T1 breast cancer-bearing mice following administering RCQ by intragastric administration. RCQ increased the recruitment of T cells and reduced the accumulation of neutrophils and macrophages in the tumor microenvironment. Meanwhile, RCQ suppressed the development of tumor-infiltrating lymphocytes into immunosuppressive cell subpopulations, including CD4(+) T cells to T helper Type 2 type (Th2), tumor-associated neutrophils (TANs) to the N2 TANs, and tumor-associated macrophages (TAMs) cells to M2 TAMs. RCQ reversed the predominance of immunosuppressive infiltrating cells in the tumor microenvironment and tipped the immune balance toward an immune activation state. In vitro the study showed that RCQ significantly increased reactive oxygen species (ROS), reduce mitochondrial membrane potentials in cancer cells, and modulate pro-apoptotic Bcl-2 family members. In conclusion, RCQ can promote the ROS apoptosis mechanism of tumor cells and alleviate immunosuppression of the tumor microenvironment to enhance the anti-tumor effect. |
format | Online Article Text |
id | pubmed-10432483 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-104324832023-08-18 The effect of resveratrol, curcumin and quercetin combination on immuno-suppression of tumor microenvironment for breast tumor-bearing mice Li, Chenchen Xu, Yajun Zhang, Junfeng Zhang, Yuxi He, Wen Ju, Jiale Wu, Yinghua Wang, Yanli Sci Rep Article Resveratrol, curcumin, and quercetin are the secondary metabolites from medicinal food homology plants, that have been proven their potency in cancer treatment. However, the antitumor effect of a single component is weak. So, herein, we designed an antitumor compound named RCQ composed of resveratrol, curcumin, and quercetin. This study examined the effect on tumorigenesis and development of 4T1 breast cancer-bearing mice following administering RCQ by intragastric administration. RCQ increased the recruitment of T cells and reduced the accumulation of neutrophils and macrophages in the tumor microenvironment. Meanwhile, RCQ suppressed the development of tumor-infiltrating lymphocytes into immunosuppressive cell subpopulations, including CD4(+) T cells to T helper Type 2 type (Th2), tumor-associated neutrophils (TANs) to the N2 TANs, and tumor-associated macrophages (TAMs) cells to M2 TAMs. RCQ reversed the predominance of immunosuppressive infiltrating cells in the tumor microenvironment and tipped the immune balance toward an immune activation state. In vitro the study showed that RCQ significantly increased reactive oxygen species (ROS), reduce mitochondrial membrane potentials in cancer cells, and modulate pro-apoptotic Bcl-2 family members. In conclusion, RCQ can promote the ROS apoptosis mechanism of tumor cells and alleviate immunosuppression of the tumor microenvironment to enhance the anti-tumor effect. Nature Publishing Group UK 2023-08-16 /pmc/articles/PMC10432483/ /pubmed/37587146 http://dx.doi.org/10.1038/s41598-023-39279-z Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Article Li, Chenchen Xu, Yajun Zhang, Junfeng Zhang, Yuxi He, Wen Ju, Jiale Wu, Yinghua Wang, Yanli The effect of resveratrol, curcumin and quercetin combination on immuno-suppression of tumor microenvironment for breast tumor-bearing mice |
title | The effect of resveratrol, curcumin and quercetin combination on immuno-suppression of tumor microenvironment for breast tumor-bearing mice |
title_full | The effect of resveratrol, curcumin and quercetin combination on immuno-suppression of tumor microenvironment for breast tumor-bearing mice |
title_fullStr | The effect of resveratrol, curcumin and quercetin combination on immuno-suppression of tumor microenvironment for breast tumor-bearing mice |
title_full_unstemmed | The effect of resveratrol, curcumin and quercetin combination on immuno-suppression of tumor microenvironment for breast tumor-bearing mice |
title_short | The effect of resveratrol, curcumin and quercetin combination on immuno-suppression of tumor microenvironment for breast tumor-bearing mice |
title_sort | effect of resveratrol, curcumin and quercetin combination on immuno-suppression of tumor microenvironment for breast tumor-bearing mice |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10432483/ https://www.ncbi.nlm.nih.gov/pubmed/37587146 http://dx.doi.org/10.1038/s41598-023-39279-z |
work_keys_str_mv | AT lichenchen theeffectofresveratrolcurcuminandquercetincombinationonimmunosuppressionoftumormicroenvironmentforbreasttumorbearingmice AT xuyajun theeffectofresveratrolcurcuminandquercetincombinationonimmunosuppressionoftumormicroenvironmentforbreasttumorbearingmice AT zhangjunfeng theeffectofresveratrolcurcuminandquercetincombinationonimmunosuppressionoftumormicroenvironmentforbreasttumorbearingmice AT zhangyuxi theeffectofresveratrolcurcuminandquercetincombinationonimmunosuppressionoftumormicroenvironmentforbreasttumorbearingmice AT hewen theeffectofresveratrolcurcuminandquercetincombinationonimmunosuppressionoftumormicroenvironmentforbreasttumorbearingmice AT jujiale theeffectofresveratrolcurcuminandquercetincombinationonimmunosuppressionoftumormicroenvironmentforbreasttumorbearingmice AT wuyinghua theeffectofresveratrolcurcuminandquercetincombinationonimmunosuppressionoftumormicroenvironmentforbreasttumorbearingmice AT wangyanli theeffectofresveratrolcurcuminandquercetincombinationonimmunosuppressionoftumormicroenvironmentforbreasttumorbearingmice AT lichenchen effectofresveratrolcurcuminandquercetincombinationonimmunosuppressionoftumormicroenvironmentforbreasttumorbearingmice AT xuyajun effectofresveratrolcurcuminandquercetincombinationonimmunosuppressionoftumormicroenvironmentforbreasttumorbearingmice AT zhangjunfeng effectofresveratrolcurcuminandquercetincombinationonimmunosuppressionoftumormicroenvironmentforbreasttumorbearingmice AT zhangyuxi effectofresveratrolcurcuminandquercetincombinationonimmunosuppressionoftumormicroenvironmentforbreasttumorbearingmice AT hewen effectofresveratrolcurcuminandquercetincombinationonimmunosuppressionoftumormicroenvironmentforbreasttumorbearingmice AT jujiale effectofresveratrolcurcuminandquercetincombinationonimmunosuppressionoftumormicroenvironmentforbreasttumorbearingmice AT wuyinghua effectofresveratrolcurcuminandquercetincombinationonimmunosuppressionoftumormicroenvironmentforbreasttumorbearingmice AT wangyanli effectofresveratrolcurcuminandquercetincombinationonimmunosuppressionoftumormicroenvironmentforbreasttumorbearingmice |