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Novel technique for amniotic membrane transplantation for acute Stevens-Johnson syndrome/toxic epidermal necrolysis patients

PURPOSE: To report a novel technique to facilitate amniotic membrane transplantation (AMT) for acute stage Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN). DESIGN: Laboratory investigation and retrospective, single-center case series. METHODS: The polylactic acid (PLA) amniotic f...

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Autores principales: Zhang, Nan, Geng, Xingchen, Liu, Ruixing, Liu, Xiaowu, Cui, Haohao, Dou, Runan, Hou, Songlin, Li, Jingguo, Zhu, Lei, Li, Zhanrong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10432697/
https://www.ncbi.nlm.nih.gov/pubmed/37600383
http://dx.doi.org/10.1016/j.heliyon.2023.e18853
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author Zhang, Nan
Geng, Xingchen
Liu, Ruixing
Liu, Xiaowu
Cui, Haohao
Dou, Runan
Hou, Songlin
Li, Jingguo
Zhu, Lei
Li, Zhanrong
author_facet Zhang, Nan
Geng, Xingchen
Liu, Ruixing
Liu, Xiaowu
Cui, Haohao
Dou, Runan
Hou, Songlin
Li, Jingguo
Zhu, Lei
Li, Zhanrong
author_sort Zhang, Nan
collection PubMed
description PURPOSE: To report a novel technique to facilitate amniotic membrane transplantation (AMT) for acute stage Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN). DESIGN: Laboratory investigation and retrospective, single-center case series. METHODS: The polylactic acid (PLA) amniotic fornical ring (AFR) have been successfully manufactured by three-dimensional (3D) printing technology for AMT. This study retrospectively analyzed the medical records of 5 SJS/TEN patients at the acute stage between 2019 and 2023. Patients were surgically treated with AFR or sutured amniotic membrane transplant (SAMT). Epidemiology, best-corrected visual acuity (BCVA), acute ocular severity score, operative duration, epithelial healing time, amniotic dissolution and follow-up time were evaluated. RESULTS: Of all five patients, three patients (6 eyes) received AFR/AMT (Group A), and 2 patients (4 eyes) received SAMT (Group B). There were no significant differences between two groups in the mean preoperative days and vision changes. The mean operation duration was 11.7 ± 3.8 mins in group A. Compared with the SAMT (48.8 ± 5.3 mins), the operation duration was reduced by 76.02%. The mean times for epithelial healing were 32.5 ± 29.2 days in group A and 12.0 ± 0.0 days in group B. In addition, there were no significant side effects of 3D-printed sterile AFR on the eyes. CONCLUSIONS: 3D-printed PLA scaffolds could be used as an AFR device for acute SJS/TEN. In addition, personalized 3D-printed AFR is superior to conventional SAMT in operation duration.
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spelling pubmed-104326972023-08-18 Novel technique for amniotic membrane transplantation for acute Stevens-Johnson syndrome/toxic epidermal necrolysis patients Zhang, Nan Geng, Xingchen Liu, Ruixing Liu, Xiaowu Cui, Haohao Dou, Runan Hou, Songlin Li, Jingguo Zhu, Lei Li, Zhanrong Heliyon Case Report PURPOSE: To report a novel technique to facilitate amniotic membrane transplantation (AMT) for acute stage Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN). DESIGN: Laboratory investigation and retrospective, single-center case series. METHODS: The polylactic acid (PLA) amniotic fornical ring (AFR) have been successfully manufactured by three-dimensional (3D) printing technology for AMT. This study retrospectively analyzed the medical records of 5 SJS/TEN patients at the acute stage between 2019 and 2023. Patients were surgically treated with AFR or sutured amniotic membrane transplant (SAMT). Epidemiology, best-corrected visual acuity (BCVA), acute ocular severity score, operative duration, epithelial healing time, amniotic dissolution and follow-up time were evaluated. RESULTS: Of all five patients, three patients (6 eyes) received AFR/AMT (Group A), and 2 patients (4 eyes) received SAMT (Group B). There were no significant differences between two groups in the mean preoperative days and vision changes. The mean operation duration was 11.7 ± 3.8 mins in group A. Compared with the SAMT (48.8 ± 5.3 mins), the operation duration was reduced by 76.02%. The mean times for epithelial healing were 32.5 ± 29.2 days in group A and 12.0 ± 0.0 days in group B. In addition, there were no significant side effects of 3D-printed sterile AFR on the eyes. CONCLUSIONS: 3D-printed PLA scaffolds could be used as an AFR device for acute SJS/TEN. In addition, personalized 3D-printed AFR is superior to conventional SAMT in operation duration. Elsevier 2023-08-07 /pmc/articles/PMC10432697/ /pubmed/37600383 http://dx.doi.org/10.1016/j.heliyon.2023.e18853 Text en © 2023 The Authors https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Case Report
Zhang, Nan
Geng, Xingchen
Liu, Ruixing
Liu, Xiaowu
Cui, Haohao
Dou, Runan
Hou, Songlin
Li, Jingguo
Zhu, Lei
Li, Zhanrong
Novel technique for amniotic membrane transplantation for acute Stevens-Johnson syndrome/toxic epidermal necrolysis patients
title Novel technique for amniotic membrane transplantation for acute Stevens-Johnson syndrome/toxic epidermal necrolysis patients
title_full Novel technique for amniotic membrane transplantation for acute Stevens-Johnson syndrome/toxic epidermal necrolysis patients
title_fullStr Novel technique for amniotic membrane transplantation for acute Stevens-Johnson syndrome/toxic epidermal necrolysis patients
title_full_unstemmed Novel technique for amniotic membrane transplantation for acute Stevens-Johnson syndrome/toxic epidermal necrolysis patients
title_short Novel technique for amniotic membrane transplantation for acute Stevens-Johnson syndrome/toxic epidermal necrolysis patients
title_sort novel technique for amniotic membrane transplantation for acute stevens-johnson syndrome/toxic epidermal necrolysis patients
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10432697/
https://www.ncbi.nlm.nih.gov/pubmed/37600383
http://dx.doi.org/10.1016/j.heliyon.2023.e18853
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