Hypermethylation of RNF125 promotes autophagy-induced oxidative stress in asthma by increasing HMGB1 stability

Asthma is a global chronic airway disease. The expression and role of RNF125, an E3 ubiquitin ligase, in asthma remain uncertain. In this study, we revealed that RNF125 was downregulated in the bronchial epithelium of mice and patients with asthma. Rnf125 hypermethylation was responsible for the low...

Descripción completa

Detalles Bibliográficos
Autores principales: Hu, Jiapeng, Ding, Ruiwei, Liu, Shaozhuang, Wang, Jia, Li, Jianjun, Shang, Yunxiao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10432822/
https://www.ncbi.nlm.nih.gov/pubmed/37599832
http://dx.doi.org/10.1016/j.isci.2023.107503

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10432822/
https://www.ncbi.nlm.nih.gov/pubmed/37599832
http://dx.doi.org/10.1016/j.isci.2023.107503

Ejemplares similares