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Clustering molecular dynamics conformations of the CC’-loop of the PD-1 immuno-checkpoint receptor
Molecular mechanisms within the checkpoint receptor PD-1 are essential for its activation by PD-L1 as well as for blocking such an activation via checkpoint inhibitors. We use molecular dynamics to scrutinize patterns of atomic motion in PD-1 without a ligand. Molecular dynamics is performed for the...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Research Network of Computational and Structural Biotechnology
2023
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10432919/ https://www.ncbi.nlm.nih.gov/pubmed/37602229 http://dx.doi.org/10.1016/j.csbj.2023.07.004 |