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Stem Cell Therapy in Stargardt Disease: A Systematic Review
This article aimed to review current literature on the safety and efficacy of stem cell therapy in Stargardt disease. A comprehensive literature search was performed, and two animal and eleven human clinical trials were retrieved. These studies utilized different kinds of stem cells, including human...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
PUBLISHED BY KNOWLEDGE E
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10432931/ https://www.ncbi.nlm.nih.gov/pubmed/37600916 http://dx.doi.org/10.18502/jovr.v18i3.13780 |
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author | Moghadam Fard, Atousa Mirshahi, Reza Naseripour, Masood Ghasemi Falavarjani, Khalil |
author_facet | Moghadam Fard, Atousa Mirshahi, Reza Naseripour, Masood Ghasemi Falavarjani, Khalil |
author_sort | Moghadam Fard, Atousa |
collection | PubMed |
description | This article aimed to review current literature on the safety and efficacy of stem cell therapy in Stargardt disease. A comprehensive literature search was performed, and two animal and eleven human clinical trials were retrieved. These studies utilized different kinds of stem cells, including human or mouse embryonic stem cells, mesenchymal stem cells, bone marrow mononuclear fraction, and autologous bone marrow-derived stem cells. In addition, different injection techniques including subretinal, intravitreal, and suprachoroidal space injections have been evaluated. Although stem cell therapy holds promise in improving visual function in patients with Stargardt disease, further investigation is needed to determine the long-term benefits, safety, and efficacy in determining the best delivery method and selecting the most appropriate stem cell type. |
format | Online Article Text |
id | pubmed-10432931 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | PUBLISHED BY KNOWLEDGE E |
record_format | MEDLINE/PubMed |
spelling | pubmed-104329312023-08-18 Stem Cell Therapy in Stargardt Disease: A Systematic Review Moghadam Fard, Atousa Mirshahi, Reza Naseripour, Masood Ghasemi Falavarjani, Khalil J Ophthalmic Vis Res Review Article This article aimed to review current literature on the safety and efficacy of stem cell therapy in Stargardt disease. A comprehensive literature search was performed, and two animal and eleven human clinical trials were retrieved. These studies utilized different kinds of stem cells, including human or mouse embryonic stem cells, mesenchymal stem cells, bone marrow mononuclear fraction, and autologous bone marrow-derived stem cells. In addition, different injection techniques including subretinal, intravitreal, and suprachoroidal space injections have been evaluated. Although stem cell therapy holds promise in improving visual function in patients with Stargardt disease, further investigation is needed to determine the long-term benefits, safety, and efficacy in determining the best delivery method and selecting the most appropriate stem cell type. PUBLISHED BY KNOWLEDGE E 2023-07-28 /pmc/articles/PMC10432931/ /pubmed/37600916 http://dx.doi.org/10.18502/jovr.v18i3.13780 Text en Copyright © 2023 Moghadam Fard et al. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Moghadam Fard, Atousa Mirshahi, Reza Naseripour, Masood Ghasemi Falavarjani, Khalil Stem Cell Therapy in Stargardt Disease: A Systematic Review |
title | Stem Cell Therapy in Stargardt Disease: A Systematic Review |
title_full | Stem Cell Therapy in Stargardt Disease: A Systematic Review |
title_fullStr | Stem Cell Therapy in Stargardt Disease: A Systematic Review |
title_full_unstemmed | Stem Cell Therapy in Stargardt Disease: A Systematic Review |
title_short | Stem Cell Therapy in Stargardt Disease: A Systematic Review |
title_sort | stem cell therapy in stargardt disease: a systematic review |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10432931/ https://www.ncbi.nlm.nih.gov/pubmed/37600916 http://dx.doi.org/10.18502/jovr.v18i3.13780 |
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