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Stem Cell Therapy in Stargardt Disease: A Systematic Review

This article aimed to review current literature on the safety and efficacy of stem cell therapy in Stargardt disease. A comprehensive literature search was performed, and two animal and eleven human clinical trials were retrieved. These studies utilized different kinds of stem cells, including human...

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Autores principales: Moghadam Fard, Atousa, Mirshahi, Reza, Naseripour, Masood, Ghasemi Falavarjani, Khalil
Formato: Online Artículo Texto
Lenguaje:English
Publicado: PUBLISHED BY KNOWLEDGE E 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10432931/
https://www.ncbi.nlm.nih.gov/pubmed/37600916
http://dx.doi.org/10.18502/jovr.v18i3.13780
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author Moghadam Fard, Atousa
Mirshahi, Reza
Naseripour, Masood
Ghasemi Falavarjani, Khalil
author_facet Moghadam Fard, Atousa
Mirshahi, Reza
Naseripour, Masood
Ghasemi Falavarjani, Khalil
author_sort Moghadam Fard, Atousa
collection PubMed
description This article aimed to review current literature on the safety and efficacy of stem cell therapy in Stargardt disease. A comprehensive literature search was performed, and two animal and eleven human clinical trials were retrieved. These studies utilized different kinds of stem cells, including human or mouse embryonic stem cells, mesenchymal stem cells, bone marrow mononuclear fraction, and autologous bone marrow-derived stem cells. In addition, different injection techniques including subretinal, intravitreal, and suprachoroidal space injections have been evaluated. Although stem cell therapy holds promise in improving visual function in patients with Stargardt disease, further investigation is needed to determine the long-term benefits, safety, and efficacy in determining the best delivery method and selecting the most appropriate stem cell type.
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spelling pubmed-104329312023-08-18 Stem Cell Therapy in Stargardt Disease: A Systematic Review Moghadam Fard, Atousa Mirshahi, Reza Naseripour, Masood Ghasemi Falavarjani, Khalil J Ophthalmic Vis Res Review Article This article aimed to review current literature on the safety and efficacy of stem cell therapy in Stargardt disease. A comprehensive literature search was performed, and two animal and eleven human clinical trials were retrieved. These studies utilized different kinds of stem cells, including human or mouse embryonic stem cells, mesenchymal stem cells, bone marrow mononuclear fraction, and autologous bone marrow-derived stem cells. In addition, different injection techniques including subretinal, intravitreal, and suprachoroidal space injections have been evaluated. Although stem cell therapy holds promise in improving visual function in patients with Stargardt disease, further investigation is needed to determine the long-term benefits, safety, and efficacy in determining the best delivery method and selecting the most appropriate stem cell type. PUBLISHED BY KNOWLEDGE E 2023-07-28 /pmc/articles/PMC10432931/ /pubmed/37600916 http://dx.doi.org/10.18502/jovr.v18i3.13780 Text en Copyright © 2023 Moghadam Fard et al. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Moghadam Fard, Atousa
Mirshahi, Reza
Naseripour, Masood
Ghasemi Falavarjani, Khalil
Stem Cell Therapy in Stargardt Disease: A Systematic Review
title Stem Cell Therapy in Stargardt Disease: A Systematic Review
title_full Stem Cell Therapy in Stargardt Disease: A Systematic Review
title_fullStr Stem Cell Therapy in Stargardt Disease: A Systematic Review
title_full_unstemmed Stem Cell Therapy in Stargardt Disease: A Systematic Review
title_short Stem Cell Therapy in Stargardt Disease: A Systematic Review
title_sort stem cell therapy in stargardt disease: a systematic review
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10432931/
https://www.ncbi.nlm.nih.gov/pubmed/37600916
http://dx.doi.org/10.18502/jovr.v18i3.13780
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