Assessment of clinical characteristics and viral load in individuals infected by Delta and Omicron variants of SARS-CoV-2

In late 2021, a new variant of SARS-CoV-2 called Omicron emerged, replacing Delta worldwide. Although it has been associated with a lower risk of hospitalization and severe forms of COVID-19, there is little evidence of its relationship with specific symptoms and viral load. The aim of this study wa...

Descripción completa

Detalles Bibliográficos
Autores principales: Nunes, Sávio Luiz Pereira, de França, Chirles Araújo, Rocha, Gabriela Dias, Oliveira, Samily Aquino de Sá, Freitas, Mariana Ramos, da Silva, Eliane Oliveira, Coutinho, Katia Sampaio, Jerônimo, Aline Silva, de Lima, Gustavo Barbosa, de Lima, Raul Emídio, Bezerra, Matheus Filgueira, Dezordi, Filipe Zimmer, Paiva, Marcelo Henrique Santos, Wallau, Gabriel da Luz, de Souza, Carlos Dornels Freire, Armstrong, Anderson da Costa, do Carmo, Rodrigo Feliciano
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10432967/
https://www.ncbi.nlm.nih.gov/pubmed/37600420
http://dx.doi.org/10.1016/j.heliyon.2023.e18994
Descripción
Sumario:In late 2021, a new variant of SARS-CoV-2 called Omicron emerged, replacing Delta worldwide. Although it has been associated with a lower risk of hospitalization and severe forms of COVID-19, there is little evidence of its relationship with specific symptoms and viral load. The aim of this study was to verify the relationship between Delta and Omicron variants of concern, viral load, and the occurrence of symptoms in individuals with COVID-19. Nasopharyngeal swab samples were collected and sequenced from patients with COVID-19 from the Northeast Region of Brazil between August 2021 and March 2022. The results showed a gradual replacement of the Delta variant by the Omicron variant during the study period. A total of 316 samples (157 Delta and 159 Omicron) were included. There was a higher prevalence of symptoms in Delta-infected individuals, such as coryza, olfactory and taste disturbances, headache, and myalgia. There was no association between viral load and the variants analyzed. The results reported here contribute to the understanding of the symptoms associated with the Delta and Omicron variants in individuals affected by COVID-19.

Ejemplares similares