Cargando…

Sonolytic degradation kinetics and mechanisms of antibiotics in water and cow milk()

Antibiotics (ABX) residues frequently occurred in water and cow milk. This work aims to understand the kinetics and mechanisms of sonolytic degradation of four ABX, i.e. ceftiofur hydrochloride (CEF), sulfamonomethoxine sodium (SMM), marbofloxacin (MAR), and oxytetracycline (OTC) in water and milk....

Descripción completa

Detalles Bibliográficos
Autores principales: Liu, Pengyun, Wu, Zhilin, Fang, Zhen, Cravotto, Giancarlo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10433014/
https://www.ncbi.nlm.nih.gov/pubmed/37572426
http://dx.doi.org/10.1016/j.ultsonch.2023.106518
_version_ 1785091556030545920
author Liu, Pengyun
Wu, Zhilin
Fang, Zhen
Cravotto, Giancarlo
author_facet Liu, Pengyun
Wu, Zhilin
Fang, Zhen
Cravotto, Giancarlo
author_sort Liu, Pengyun
collection PubMed
description Antibiotics (ABX) residues frequently occurred in water and cow milk. This work aims to understand the kinetics and mechanisms of sonolytic degradation of four ABX, i.e. ceftiofur hydrochloride (CEF), sulfamonomethoxine sodium (SMM), marbofloxacin (MAR), and oxytetracycline (OTC) in water and milk. In both water and milk, the sonolytic degradation of ABX follows pseudo-first order (PFO) kinetics well (R(2): 0.951–0.999), with significantly faster ABX degradation in water (PFO kinetics constants (k(1)): 1.5 × 10(−3)-1.2 × 10(−1) min(−1)) than in milk (k(1): 3.5 × 10(−4)-5.6 × 10(−2) min(−1)). The k(1) values for SMM degradation in water increased by 118% with ultrasonic frequency (40–120 kHz), 174% with ultrasonic frequency (80–500 kHz), 649% with ultrasonic power (73–259 W), 22% with bulk temperature (12–40℃), and by 68% with reaction volume (50–250 mL), respectively, in other things being equal. The relevant k(1) values in milk increased by 326%, 231%, 122%, 10% as well as 82% with the above same effective factors, respectively. The oxidation by free radicals generated in situ dominates ABX degradation, and the hydrophobic CEF (54.0–971.7 nM min(−1)) and SMM (39.2–798.4 nM min(−1)) underwent faster degradation than the hydrophilic MAR (33.9–751.9 nM min(−1)) and OTC (33.8–545.3 nM min(−1)) in both water and milk. Adding an extra 0.5 mM H(2)O(2) accelerated SMM degradation by 19% in water and 33% in milk. After 130–150 min sonication of 100 mL of 2.0 mg L(−1) (6.62 μM) SMM in various milk with 500 kHz and 259 W, the residue concentrations (52.9–96.3 μg L(−1)) can meet the relevant maximum residue limit (100 μg L(−1)).
format Online
Article
Text
id pubmed-10433014
institution National Center for Biotechnology Information
language English
publishDate 2023
publisher Elsevier
record_format MEDLINE/PubMed
spelling pubmed-104330142023-08-18 Sonolytic degradation kinetics and mechanisms of antibiotics in water and cow milk() Liu, Pengyun Wu, Zhilin Fang, Zhen Cravotto, Giancarlo Ultrason Sonochem UC and HC intensification Antibiotics (ABX) residues frequently occurred in water and cow milk. This work aims to understand the kinetics and mechanisms of sonolytic degradation of four ABX, i.e. ceftiofur hydrochloride (CEF), sulfamonomethoxine sodium (SMM), marbofloxacin (MAR), and oxytetracycline (OTC) in water and milk. In both water and milk, the sonolytic degradation of ABX follows pseudo-first order (PFO) kinetics well (R(2): 0.951–0.999), with significantly faster ABX degradation in water (PFO kinetics constants (k(1)): 1.5 × 10(−3)-1.2 × 10(−1) min(−1)) than in milk (k(1): 3.5 × 10(−4)-5.6 × 10(−2) min(−1)). The k(1) values for SMM degradation in water increased by 118% with ultrasonic frequency (40–120 kHz), 174% with ultrasonic frequency (80–500 kHz), 649% with ultrasonic power (73–259 W), 22% with bulk temperature (12–40℃), and by 68% with reaction volume (50–250 mL), respectively, in other things being equal. The relevant k(1) values in milk increased by 326%, 231%, 122%, 10% as well as 82% with the above same effective factors, respectively. The oxidation by free radicals generated in situ dominates ABX degradation, and the hydrophobic CEF (54.0–971.7 nM min(−1)) and SMM (39.2–798.4 nM min(−1)) underwent faster degradation than the hydrophilic MAR (33.9–751.9 nM min(−1)) and OTC (33.8–545.3 nM min(−1)) in both water and milk. Adding an extra 0.5 mM H(2)O(2) accelerated SMM degradation by 19% in water and 33% in milk. After 130–150 min sonication of 100 mL of 2.0 mg L(−1) (6.62 μM) SMM in various milk with 500 kHz and 259 W, the residue concentrations (52.9–96.3 μg L(−1)) can meet the relevant maximum residue limit (100 μg L(−1)). Elsevier 2023-07-26 /pmc/articles/PMC10433014/ /pubmed/37572426 http://dx.doi.org/10.1016/j.ultsonch.2023.106518 Text en © 2023 The Author(s) https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle UC and HC intensification
Liu, Pengyun
Wu, Zhilin
Fang, Zhen
Cravotto, Giancarlo
Sonolytic degradation kinetics and mechanisms of antibiotics in water and cow milk()
title Sonolytic degradation kinetics and mechanisms of antibiotics in water and cow milk()
title_full Sonolytic degradation kinetics and mechanisms of antibiotics in water and cow milk()
title_fullStr Sonolytic degradation kinetics and mechanisms of antibiotics in water and cow milk()
title_full_unstemmed Sonolytic degradation kinetics and mechanisms of antibiotics in water and cow milk()
title_short Sonolytic degradation kinetics and mechanisms of antibiotics in water and cow milk()
title_sort sonolytic degradation kinetics and mechanisms of antibiotics in water and cow milk()
topic UC and HC intensification
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10433014/
https://www.ncbi.nlm.nih.gov/pubmed/37572426
http://dx.doi.org/10.1016/j.ultsonch.2023.106518
work_keys_str_mv AT liupengyun sonolyticdegradationkineticsandmechanismsofantibioticsinwaterandcowmilk
AT wuzhilin sonolyticdegradationkineticsandmechanismsofantibioticsinwaterandcowmilk
AT fangzhen sonolyticdegradationkineticsandmechanismsofantibioticsinwaterandcowmilk
AT cravottogiancarlo sonolyticdegradationkineticsandmechanismsofantibioticsinwaterandcowmilk