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Anterior segment optical coherence tomography features of ocular surface squamous epithelial hyperplasia: A report of four cases
Herein, we report the clinico-tomographic and histopathological features of four patients with biopsy-proven ocular surface squamous epithelial hyperplasia (OSSEH), a close mimicker of ocular surface squamous neoplasia (OSSN). The mean age at diagnosis was 58 years (median, 60 years; range, 35–77 ye...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Wolters Kluwer - Medknow
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10433064/ https://www.ncbi.nlm.nih.gov/pubmed/37602154 http://dx.doi.org/10.4103/ojo.ojo_173_22 |
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author | Vempuluru, Vijitha S. Ghose, Neha Jakati, Saumya Kaliki, Swathi |
author_facet | Vempuluru, Vijitha S. Ghose, Neha Jakati, Saumya Kaliki, Swathi |
author_sort | Vempuluru, Vijitha S. |
collection | PubMed |
description | Herein, we report the clinico-tomographic and histopathological features of four patients with biopsy-proven ocular surface squamous epithelial hyperplasia (OSSEH), a close mimicker of ocular surface squamous neoplasia (OSSN). The mean age at diagnosis was 58 years (median, 60 years; range, 35–77 years). All lesions were unilateral. Isolated corneal plaque was seen in 50% (n = 2) and nodular lesion at the nasal limbus in 50% (n = 2). Keratinization was seen in 75% (n = 3) of lesions and intrinsic vessels in 75% (n = 3). A clinical diagnosis of OSSN was made in all cases. Anterior segment optical coherence tomography (ASOCT) revealed mild epithelial hyperreflectivity in 100% (n = 4). The epithelium was normal in thickness in 75% (n = 3) and showed mild thickening in 25% (n = 1). Only 25% (n = 1) showed abrupt transition in epithelial thickness from the contiguous corneal epithelium. Histopathological examination revealed hyperplastic squamous epithelium and no cellular atypia in all cases. Stable ocular surface and no recurrences were noted at a mean follow-up of 17 months (median, 11 months; range, 2–43 months). Although OSSEH can mimic OSSN clinically, the presence of mild epithelial hyperreflectivity, lack of epithelial thickening, absence of abrupt transition from normal epithelium, and presence of subepithelial hyperreflectivity on ASOCT favor the diagnosis of OSSEH. |
format | Online Article Text |
id | pubmed-10433064 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Wolters Kluwer - Medknow |
record_format | MEDLINE/PubMed |
spelling | pubmed-104330642023-08-18 Anterior segment optical coherence tomography features of ocular surface squamous epithelial hyperplasia: A report of four cases Vempuluru, Vijitha S. Ghose, Neha Jakati, Saumya Kaliki, Swathi Oman J Ophthalmol Case Series Herein, we report the clinico-tomographic and histopathological features of four patients with biopsy-proven ocular surface squamous epithelial hyperplasia (OSSEH), a close mimicker of ocular surface squamous neoplasia (OSSN). The mean age at diagnosis was 58 years (median, 60 years; range, 35–77 years). All lesions were unilateral. Isolated corneal plaque was seen in 50% (n = 2) and nodular lesion at the nasal limbus in 50% (n = 2). Keratinization was seen in 75% (n = 3) of lesions and intrinsic vessels in 75% (n = 3). A clinical diagnosis of OSSN was made in all cases. Anterior segment optical coherence tomography (ASOCT) revealed mild epithelial hyperreflectivity in 100% (n = 4). The epithelium was normal in thickness in 75% (n = 3) and showed mild thickening in 25% (n = 1). Only 25% (n = 1) showed abrupt transition in epithelial thickness from the contiguous corneal epithelium. Histopathological examination revealed hyperplastic squamous epithelium and no cellular atypia in all cases. Stable ocular surface and no recurrences were noted at a mean follow-up of 17 months (median, 11 months; range, 2–43 months). Although OSSEH can mimic OSSN clinically, the presence of mild epithelial hyperreflectivity, lack of epithelial thickening, absence of abrupt transition from normal epithelium, and presence of subepithelial hyperreflectivity on ASOCT favor the diagnosis of OSSEH. Wolters Kluwer - Medknow 2023-06-27 /pmc/articles/PMC10433064/ /pubmed/37602154 http://dx.doi.org/10.4103/ojo.ojo_173_22 Text en Copyright: © 2023 Oman Ophthalmic Society https://creativecommons.org/licenses/by-nc-sa/4.0/This is an open access journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms. |
spellingShingle | Case Series Vempuluru, Vijitha S. Ghose, Neha Jakati, Saumya Kaliki, Swathi Anterior segment optical coherence tomography features of ocular surface squamous epithelial hyperplasia: A report of four cases |
title | Anterior segment optical coherence tomography features of ocular surface squamous epithelial hyperplasia: A report of four cases |
title_full | Anterior segment optical coherence tomography features of ocular surface squamous epithelial hyperplasia: A report of four cases |
title_fullStr | Anterior segment optical coherence tomography features of ocular surface squamous epithelial hyperplasia: A report of four cases |
title_full_unstemmed | Anterior segment optical coherence tomography features of ocular surface squamous epithelial hyperplasia: A report of four cases |
title_short | Anterior segment optical coherence tomography features of ocular surface squamous epithelial hyperplasia: A report of four cases |
title_sort | anterior segment optical coherence tomography features of ocular surface squamous epithelial hyperplasia: a report of four cases |
topic | Case Series |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10433064/ https://www.ncbi.nlm.nih.gov/pubmed/37602154 http://dx.doi.org/10.4103/ojo.ojo_173_22 |
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