ZXDC enhances cervical cancer metastasis through IGF2BP3-mediated activation of RhoA/ROCK signaling

Metastasis in cervical cancer (CC) has a significant negative impact on patient survival, highlighting the urgent need for investigation in this area. In this study, we identified significant overexpression of zinc finger, X-linked, duplicated family member C (ZXDC) in CC tissue with metastasis, whi...

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Autores principales: Mao, Yifang, Jiang, Xingyu, Guo, Peng, Ouyang, Ying, Chen, Xiangfu, Xia, Meng, Wu, Lixin, Tang, Zihao, Liang, Tianyi, Li, Yue, He, Mian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10433122/
https://www.ncbi.nlm.nih.gov/pubmed/37599824
http://dx.doi.org/10.1016/j.isci.2023.107447
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author Mao, Yifang
Jiang, Xingyu
Guo, Peng
Ouyang, Ying
Chen, Xiangfu
Xia, Meng
Wu, Lixin
Tang, Zihao
Liang, Tianyi
Li, Yue
He, Mian
author_facet Mao, Yifang
Jiang, Xingyu
Guo, Peng
Ouyang, Ying
Chen, Xiangfu
Xia, Meng
Wu, Lixin
Tang, Zihao
Liang, Tianyi
Li, Yue
He, Mian
author_sort Mao, Yifang
collection PubMed
description Metastasis in cervical cancer (CC) has a significant negative impact on patient survival, highlighting the urgent need for investigation in this area. In this study, we identified significant overexpression of zinc finger, X-linked, duplicated family member C (ZXDC) in CC tissue with metastasis, which correlates with poor outcomes for CC patients. We observed that overexpression of ZXDC promotes, while silencing of ZXDC inhibits the metastasis of CC cells both in vitro and in vivo. Additionally, our research demonstrated that ZXDC activated RhoA/ROCK signaling pathway, leading to enhanced cytoskeleton remodeling in CC cells. Besides, we found that IGF2BP3 plays an essential role in the activation of ZXDC on the RhoA/ROCK signaling pathway by stabilizing RhoA mRNA. These findings reveal a mechanism whereby ZXDC promotes the cervical cancer metastasis by targeting IGF2BP3/RhoA/ROCK pathway.
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spelling pubmed-104331222023-08-18 ZXDC enhances cervical cancer metastasis through IGF2BP3-mediated activation of RhoA/ROCK signaling Mao, Yifang Jiang, Xingyu Guo, Peng Ouyang, Ying Chen, Xiangfu Xia, Meng Wu, Lixin Tang, Zihao Liang, Tianyi Li, Yue He, Mian iScience Article Metastasis in cervical cancer (CC) has a significant negative impact on patient survival, highlighting the urgent need for investigation in this area. In this study, we identified significant overexpression of zinc finger, X-linked, duplicated family member C (ZXDC) in CC tissue with metastasis, which correlates with poor outcomes for CC patients. We observed that overexpression of ZXDC promotes, while silencing of ZXDC inhibits the metastasis of CC cells both in vitro and in vivo. Additionally, our research demonstrated that ZXDC activated RhoA/ROCK signaling pathway, leading to enhanced cytoskeleton remodeling in CC cells. Besides, we found that IGF2BP3 plays an essential role in the activation of ZXDC on the RhoA/ROCK signaling pathway by stabilizing RhoA mRNA. These findings reveal a mechanism whereby ZXDC promotes the cervical cancer metastasis by targeting IGF2BP3/RhoA/ROCK pathway. Elsevier 2023-07-20 /pmc/articles/PMC10433122/ /pubmed/37599824 http://dx.doi.org/10.1016/j.isci.2023.107447 Text en © 2023 The Authors. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Article
Mao, Yifang
Jiang, Xingyu
Guo, Peng
Ouyang, Ying
Chen, Xiangfu
Xia, Meng
Wu, Lixin
Tang, Zihao
Liang, Tianyi
Li, Yue
He, Mian
ZXDC enhances cervical cancer metastasis through IGF2BP3-mediated activation of RhoA/ROCK signaling
title ZXDC enhances cervical cancer metastasis through IGF2BP3-mediated activation of RhoA/ROCK signaling
title_full ZXDC enhances cervical cancer metastasis through IGF2BP3-mediated activation of RhoA/ROCK signaling
title_fullStr ZXDC enhances cervical cancer metastasis through IGF2BP3-mediated activation of RhoA/ROCK signaling
title_full_unstemmed ZXDC enhances cervical cancer metastasis through IGF2BP3-mediated activation of RhoA/ROCK signaling
title_short ZXDC enhances cervical cancer metastasis through IGF2BP3-mediated activation of RhoA/ROCK signaling
title_sort zxdc enhances cervical cancer metastasis through igf2bp3-mediated activation of rhoa/rock signaling
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10433122/
https://www.ncbi.nlm.nih.gov/pubmed/37599824
http://dx.doi.org/10.1016/j.isci.2023.107447
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