Increased NMDARs in neurons and glutamine synthetase in astrocytes underlying autistic-like behaviors of Gabrb1(−/−) mice

Mutations of the GABA-A receptor subunit β1 (GABRB1) gene are found in autism patients. However, it remains unclear how mutations in Gabrb1 may lead to autism. We generated Gabrb1(−/−) mouse model, which showed autistic-like behaviors. We carried out RNA-seq on the hippocampus and found glutamatergi...

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Detalles Bibliográficos
Autores principales: Wang, Jing, Gao, Yue, Xiao, Liuyan, Lin, Yanmei, Huang, Lang, Chen, Jinfa, Liang, Guanmei, Li, Weiming, Yi, Wenjuan, Lao, Jianpei, Zhang, Bin, Gao, Tian-Ming, Zhong, Mei, Yang, Xinping
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10433130/
https://www.ncbi.nlm.nih.gov/pubmed/37599823
http://dx.doi.org/10.1016/j.isci.2023.107476

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