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Anatomical network modules of the human central nervous-craniofacial skeleton system

Anatomical network analysis (AnNA) is a systems biological framework based on network theory that enables anatomical structural analysis by incorporating modularity to model structural complexity. The human brain and facial structures exhibit close structural and functional relationships, suggestive...

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Detalles Bibliográficos
Autores principales: Qing, Gele, Jia, Fucang, Liu, Jianwei, Jiang, Xiling
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10433180/
https://www.ncbi.nlm.nih.gov/pubmed/37602256
http://dx.doi.org/10.3389/fneur.2023.1164283
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author Qing, Gele
Jia, Fucang
Liu, Jianwei
Jiang, Xiling
author_facet Qing, Gele
Jia, Fucang
Liu, Jianwei
Jiang, Xiling
author_sort Qing, Gele
collection PubMed
description Anatomical network analysis (AnNA) is a systems biological framework based on network theory that enables anatomical structural analysis by incorporating modularity to model structural complexity. The human brain and facial structures exhibit close structural and functional relationships, suggestive of a co-evolved anatomical network. The present study aimed to analyze the human head as a modular entity that comprises the central nervous system, including the brain, spinal cord, and craniofacial skeleton. An AnNA model was built using 39 anatomical nodes from the brain, spinal cord, and craniofacial skeleton. The linkages were identified using peripheral nerve supply and direct contact between structures. The Spinglass algorithm in the igraph software was applied to construct a network and identify the modules of the central nervous system-craniofacial skeleton anatomical network. Two modules were identified. These comprised an anterior module, which included the forebrain, anterior cranial base, and upper-middle face, and a posterior module, which included the midbrain, hindbrain, mandible, and posterior cranium. These findings may reflect the genetic and signaling networks that drive the mosaic central nervous system and craniofacial development and offer important systems biology perspectives for developmental disorders of craniofacial structures.
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spelling pubmed-104331802023-08-18 Anatomical network modules of the human central nervous-craniofacial skeleton system Qing, Gele Jia, Fucang Liu, Jianwei Jiang, Xiling Front Neurol Neurology Anatomical network analysis (AnNA) is a systems biological framework based on network theory that enables anatomical structural analysis by incorporating modularity to model structural complexity. The human brain and facial structures exhibit close structural and functional relationships, suggestive of a co-evolved anatomical network. The present study aimed to analyze the human head as a modular entity that comprises the central nervous system, including the brain, spinal cord, and craniofacial skeleton. An AnNA model was built using 39 anatomical nodes from the brain, spinal cord, and craniofacial skeleton. The linkages were identified using peripheral nerve supply and direct contact between structures. The Spinglass algorithm in the igraph software was applied to construct a network and identify the modules of the central nervous system-craniofacial skeleton anatomical network. Two modules were identified. These comprised an anterior module, which included the forebrain, anterior cranial base, and upper-middle face, and a posterior module, which included the midbrain, hindbrain, mandible, and posterior cranium. These findings may reflect the genetic and signaling networks that drive the mosaic central nervous system and craniofacial development and offer important systems biology perspectives for developmental disorders of craniofacial structures. Frontiers Media S.A. 2023-08-02 /pmc/articles/PMC10433180/ /pubmed/37602256 http://dx.doi.org/10.3389/fneur.2023.1164283 Text en Copyright © 2023 Qing, Jia, Liu and Jiang. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neurology
Qing, Gele
Jia, Fucang
Liu, Jianwei
Jiang, Xiling
Anatomical network modules of the human central nervous-craniofacial skeleton system
title Anatomical network modules of the human central nervous-craniofacial skeleton system
title_full Anatomical network modules of the human central nervous-craniofacial skeleton system
title_fullStr Anatomical network modules of the human central nervous-craniofacial skeleton system
title_full_unstemmed Anatomical network modules of the human central nervous-craniofacial skeleton system
title_short Anatomical network modules of the human central nervous-craniofacial skeleton system
title_sort anatomical network modules of the human central nervous-craniofacial skeleton system
topic Neurology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10433180/
https://www.ncbi.nlm.nih.gov/pubmed/37602256
http://dx.doi.org/10.3389/fneur.2023.1164283
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