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The thalamic reuniens is associated with consolidation of non-spatial memory too

The nucleus reuniens (RE) is situated in the midline thalamus and provides a key link between the hippocampus and prefrontal cortex. This anatomical relationship positions the Re as an ideal candidate to facilitate memory consolidation. However, there is no evidence that this role extends beyond spa...

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Autores principales: Hamilton, Jennifer J., Dalrymple-Alford, John C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10433182/
https://www.ncbi.nlm.nih.gov/pubmed/37600760
http://dx.doi.org/10.3389/fnbeh.2023.1215625
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author Hamilton, Jennifer J.
Dalrymple-Alford, John C.
author_facet Hamilton, Jennifer J.
Dalrymple-Alford, John C.
author_sort Hamilton, Jennifer J.
collection PubMed
description The nucleus reuniens (RE) is situated in the midline thalamus and provides a key link between the hippocampus and prefrontal cortex. This anatomical relationship positions the Re as an ideal candidate to facilitate memory consolidation. However, there is no evidence that this role extends beyond spatial memory and contextual fear memory, which are both strongly associated with hippocampal function. We, therefore, trained intact male Long–Evans rats on an odor–trace–object paired-associate task where the explicit 10-s delay between paired items renders the task sensitive to hippocampal function. Neurons in the RE showed significantly increased activation of the immediate early gene (Zif268) when rats were re-tested for previous non-spatial memory 25 days after acquisition training, compared to a group tested at 5-days post-acquisition, as well as a control group tested 25 days after acquisition but with a new pair of non-spatial stimuli, and home cage controls. The remote recall group also showed relatively augmented IEG expression in the superficial layers of the medial PFC (anterior cingulate cortex and prelimbic cortex). These findings support the conclusion that the RE is preferentially engaged during remote recall in this non-spatial task and thus has a role beyond spatial memory and contextual fear memory.
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spelling pubmed-104331822023-08-18 The thalamic reuniens is associated with consolidation of non-spatial memory too Hamilton, Jennifer J. Dalrymple-Alford, John C. Front Behav Neurosci Behavioral Neuroscience The nucleus reuniens (RE) is situated in the midline thalamus and provides a key link between the hippocampus and prefrontal cortex. This anatomical relationship positions the Re as an ideal candidate to facilitate memory consolidation. However, there is no evidence that this role extends beyond spatial memory and contextual fear memory, which are both strongly associated with hippocampal function. We, therefore, trained intact male Long–Evans rats on an odor–trace–object paired-associate task where the explicit 10-s delay between paired items renders the task sensitive to hippocampal function. Neurons in the RE showed significantly increased activation of the immediate early gene (Zif268) when rats were re-tested for previous non-spatial memory 25 days after acquisition training, compared to a group tested at 5-days post-acquisition, as well as a control group tested 25 days after acquisition but with a new pair of non-spatial stimuli, and home cage controls. The remote recall group also showed relatively augmented IEG expression in the superficial layers of the medial PFC (anterior cingulate cortex and prelimbic cortex). These findings support the conclusion that the RE is preferentially engaged during remote recall in this non-spatial task and thus has a role beyond spatial memory and contextual fear memory. Frontiers Media S.A. 2023-08-01 /pmc/articles/PMC10433182/ /pubmed/37600760 http://dx.doi.org/10.3389/fnbeh.2023.1215625 Text en Copyright © 2023 Hamilton and Dalrymple-Alford. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Behavioral Neuroscience
Hamilton, Jennifer J.
Dalrymple-Alford, John C.
The thalamic reuniens is associated with consolidation of non-spatial memory too
title The thalamic reuniens is associated with consolidation of non-spatial memory too
title_full The thalamic reuniens is associated with consolidation of non-spatial memory too
title_fullStr The thalamic reuniens is associated with consolidation of non-spatial memory too
title_full_unstemmed The thalamic reuniens is associated with consolidation of non-spatial memory too
title_short The thalamic reuniens is associated with consolidation of non-spatial memory too
title_sort thalamic reuniens is associated with consolidation of non-spatial memory too
topic Behavioral Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10433182/
https://www.ncbi.nlm.nih.gov/pubmed/37600760
http://dx.doi.org/10.3389/fnbeh.2023.1215625
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