Cargando…

Leukotriene signaling as molecular correlate for cognitive heterogeneity in aging: an exploratory study

INTRODUCTION: Aging is in general associated with a decline in cognitive functions. Looking more closely, there is a huge heterogeneity in the extent of cognitive (dys-)abilities in the aged population. It ranges from the population of resistant, resilient, cognitively unimpaired individuals to pati...

Descripción completa

Detalles Bibliográficos
Autores principales:	Mrowetz, Heike, Kotob, Mohamed H., Forster, Jennifer, Aydin, Iren, Unger, Michael Stefan, Lubec, Jana, Hussein, Ahmed M., Malikovic, Jovana, Feyissa, Daniel Daba, Korz, Volker, Höger, Harald, Lubec, Gert, Aigner, Ludwig
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2023
Materias:	Neuroscience
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10433382/ https://www.ncbi.nlm.nih.gov/pubmed/37600518 http://dx.doi.org/10.3389/fnagi.2023.1140708

Ejemplares similares

Dentate Gyrus Peroxiredoxin 6 Levels Discriminate Aged Unimpaired From Impaired Rats in a Spatial Memory Task
por: Lubec, Jana, et al.
Publicado: (2019)

Moderate Differences in Feeding Diets Largely Affect Motivation and Spatial Cognition in Adult and Aged but Less in Young Male Rats
por: Maliković, Jovana, et al.
Publicado: (2018)

Spatial Working Memory in Male Rats: Pre-Experience and Task Dependent Roles of Dopamine D1- and D2-Like Receptors
por: Bezu, Mekite, et al.
Publicado: (2017)

Age and cognitive status dependent differences in blood steroid and thyroid hormone concentrations in intact male rats
por: Maliković, Jovana, et al.
Publicado: (2019)

Striatal Transcriptome Reveals Differences Between Cognitively Impaired and Unimpaired Aged Male Rats
por: Korz, Volker, et al.
Publicado: (2021)

Differences in Hypothalamic Lipid Profiles of Young and Aged Male Rats With Impaired and Unimpaired Spatial Cognitive Abilities and Memory
por: Wackerlig, Judith, et al.
Publicado: (2020)

Individual Differences in Male Rats in a Behavioral Test Battery: A Multivariate Statistical Approach
por: Feyissa, Daniel D., et al.
Publicado: (2017)

The Lack of Dopamine Transporter Is Associated With Conditional Associative Learning Impairments and Striatal Proteomic Changes
por: Savchenko, Artem, et al.
Publicado: (2022)

Molecular species of oxidized phospholipids in brain differentiate between learning- and memory impaired and unimpaired aged rats
por: Narzt, Marie-Sophie, et al.
Publicado: (2022)

Low-Affinity/High-Selectivity Dopamine Transport Inhibition Sufficient to Rescue Cognitive Functions in the Aging Rat
por: Lubec, Jana, et al.
Publicado: (2023)

Reduced Levels of the Synaptic Functional Regulator FMRP in Dentate Gyrus of the Aging Sprague-Dawley Rat
por: Smidak, Roman, et al.
Publicado: (2017)

Concerted Gene Expression of Hippocampal Steroid Receptors during Spatial Learning in Male Wistar Rats: A Correlation Analysis
por: Lubec, Gert, et al.
Publicado: (2016)

Differential effects of wake promoting drug modafinil in aversive learning paradigms
por: Shanmugasundaram, Bharanidharan, et al.
Publicado: (2015)

A Novel Dopamine Transporter Inhibitor CE-123 Improves Cognitive Flexibility and Maintains Impulsivity in Healthy Male Rats
por: Nikiforuk, Agnieszka, et al.
Publicado: (2017)

R-Modafinil exerts weak effects on spatial memory acquisition and dentate gyrus synaptic plasticity
por: Shanmugasundaram, Bharanidharan, et al.
Publicado: (2017)

Microglia depletion diminishes key elements of the leukotriene pathway in the brain of Alzheimer’s Disease mice
por: Michael, J., et al.
Publicado: (2020)

Scopolamine Administration Modulates Muscarinic, Nicotinic and NMDA Receptor Systems
por: Falsafi, Soheil Keihan, et al.
Publicado: (2012)

Cognitive profiling and proteomic analysis of the modafinil analogue S-CE-123 in experienced aged rats
por: Gyertyán, István, et al.
Publicado: (2021)

Mouse hippocampal GABAB1 but not GABAB2 subunit-containing receptor complex levels are paralleling retrieval in the multiple-T-maze
por: Falsafi, Soheil K., et al.
Publicado: (2015)

Leukotriene Signaling as a Target in α-Synucleinopathies
por: Strempfl, Katharina, et al.
Publicado: (2022)

Spatial and Working Memory Is Linked to Spine Density and Mushroom Spines
por: Mahmmoud, Rasha Refaat, et al.
Publicado: (2015)

Platelets in Amyloidogenic Mice Are Activated and Invade the Brain
por: Kniewallner, Kathrin M., et al.
Publicado: (2020)

Comprehensive identification of age-related lipidome changes in rat amygdala during normal aging
por: Šmidák, Roman, et al.
Publicado: (2017)

The Atypical Dopamine Transporter Inhibitor CE-158 Enhances Dopamine Neurotransmission in the Prefrontal Cortex of Male Rats: A Behavioral, Electrophysiological, and Microdialysis Study
por: Sagheddu, Claudia, et al.
Publicado: (2023)

Proteomic Differences between Tellurite-Sensitive and Tellurite–Resistant E.coli
por: Aradská, Jana, et al.
Publicado: (2013)

A Novel Heterocyclic Compound CE-104 Enhances Spatial Working Memory in the Radial Arm Maze in Rats and Modulates the Dopaminergic System
por: Aher, Yogesh D., et al.
Publicado: (2016)

Allergy Enhances Neurogenesis and Modulates Microglial Activation in the Hippocampus
por: Klein, Barbara, et al.
Publicado: (2016)

Neurophysiological and Neurochemical Effects of the Putative Cognitive Enhancer (S)-CE-123 on Mesocorticolimbic Dopamine System
por: Sagheddu, Claudia, et al.
Publicado: (2020)

Immune-mediated platelet depletion augments Alzheimer’s disease neuropathological hallmarks in APP-PS1 mice
por: de Sousa, Diana M. Bessa, et al.
Publicado: (2023)

TGF-β Signaling: A Therapeutic Target to Reinstate Regenerative Plasticity in Vascular Dementia?
por: Kandasamy, Mahesh, et al.
Publicado: (2020)

Mass spectrometrical analysis of recombinant human growth hormone (Genotropin(®)) reveals amino acid substitutions in 2% of the expressed protein
por: Hepner, Felix, et al.
Publicado: (2005)

The platelet transcriptome and proteome in Alzheimer’s disease and aging: an exploratory cross-sectional study
por: de Sousa, Diana M. Bessa, et al.
Publicado: (2023)

Microglia prevent peripheral immune cell invasion and promote an anti-inflammatory environment in the brain of APP-PS1 transgenic mice
por: Unger, M. S., et al.
Publicado: (2018)

Age Influences Microglial Activation After Cuprizone-Induced Demyelination
por: Klein, Barbara, et al.
Publicado: (2018)

The Leukotriene Receptor Antagonist Montelukast Attenuates Neuroinflammation and Affects Cognition in Transgenic 5xFAD Mice
por: Michael, Johanna, et al.
Publicado: (2021)

The effect of modafinil on the rat dopamine transporter and dopamine receptors D1–D3 paralleling cognitive enhancement in the radial arm maze
por: Karabacak, Yasemin, et al.
Publicado: (2015)

Cysteinyl leukotriene receptor 1 modulates autophagic activity in retinal pigment epithelial cells
por: Koller, Andreas, et al.
Publicado: (2020)

Altered expression of hypothetical proteins in hippocampus of transgenic mice overexpressing human Cu/Zn-superoxide dismutase 1
por: Shin, Joo-Ho, et al.
Publicado: (2004)

Amniotic Fluid Stem Cells: Future Perspectives
por: Rosner, Margit, et al.
Publicado: (2012)

Manufacturing of peptides exhibiting biological activity
por: Zambrowicz, Aleksandra, et al.
Publicado: (2012)

Cannot write session to /tmp/vufind_sessions/sess_vunk08pn0d0tq43a549ub9534g