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A mathematician’s guide to plasmids: an introduction to plasmid biology for modellers

Plasmids, extrachromosomal DNA molecules commonly found in bacterial and archaeal cells, play an important role in bacterial genetics and evolution. Our understanding of plasmid biology has been furthered greatly by the development of mathematical models, and there are many questions about plasmids...

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Detalles Bibliográficos
Autores principales: Dewan, Ian, Uecker, Hildegard
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Microbiology Society 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10433428/
https://www.ncbi.nlm.nih.gov/pubmed/37505810
http://dx.doi.org/10.1099/mic.0.001362
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author Dewan, Ian
Uecker, Hildegard
author_facet Dewan, Ian
Uecker, Hildegard
author_sort Dewan, Ian
collection PubMed
description Plasmids, extrachromosomal DNA molecules commonly found in bacterial and archaeal cells, play an important role in bacterial genetics and evolution. Our understanding of plasmid biology has been furthered greatly by the development of mathematical models, and there are many questions about plasmids that models would be useful in answering. In this review, we present an introductory, yet comprehensive, overview of the biology of plasmids suitable for modellers unfamiliar with plasmids who want to get up to speed and to begin working on plasmid-related models. In addition to reviewing the diversity of plasmids and the genes they carry, their key physiological functions, and interactions between plasmid and host, we also highlight selected plasmid topics that may be of particular interest to modellers and areas where there is a particular need for theoretical development. The world of plasmids holds a great variety of subjects that will interest mathematical biologists, and introducing new modellers to the subject will help to expand the existing body of plasmid theory.
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spelling pubmed-104334282023-08-18 A mathematician’s guide to plasmids: an introduction to plasmid biology for modellers Dewan, Ian Uecker, Hildegard Microbiology (Reading) Reviews Plasmids, extrachromosomal DNA molecules commonly found in bacterial and archaeal cells, play an important role in bacterial genetics and evolution. Our understanding of plasmid biology has been furthered greatly by the development of mathematical models, and there are many questions about plasmids that models would be useful in answering. In this review, we present an introductory, yet comprehensive, overview of the biology of plasmids suitable for modellers unfamiliar with plasmids who want to get up to speed and to begin working on plasmid-related models. In addition to reviewing the diversity of plasmids and the genes they carry, their key physiological functions, and interactions between plasmid and host, we also highlight selected plasmid topics that may be of particular interest to modellers and areas where there is a particular need for theoretical development. The world of plasmids holds a great variety of subjects that will interest mathematical biologists, and introducing new modellers to the subject will help to expand the existing body of plasmid theory. Microbiology Society 2023-07-28 /pmc/articles/PMC10433428/ /pubmed/37505810 http://dx.doi.org/10.1099/mic.0.001362 Text en © 2023 The Authors https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License. This article was made open access via a Publish and Read agreement between the Microbiology Society and the corresponding author’s institution.
spellingShingle Reviews
Dewan, Ian
Uecker, Hildegard
A mathematician’s guide to plasmids: an introduction to plasmid biology for modellers
title A mathematician’s guide to plasmids: an introduction to plasmid biology for modellers
title_full A mathematician’s guide to plasmids: an introduction to plasmid biology for modellers
title_fullStr A mathematician’s guide to plasmids: an introduction to plasmid biology for modellers
title_full_unstemmed A mathematician’s guide to plasmids: an introduction to plasmid biology for modellers
title_short A mathematician’s guide to plasmids: an introduction to plasmid biology for modellers
title_sort mathematician’s guide to plasmids: an introduction to plasmid biology for modellers
topic Reviews
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10433428/
https://www.ncbi.nlm.nih.gov/pubmed/37505810
http://dx.doi.org/10.1099/mic.0.001362
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