Uncoupling of Ca(2+) sparks from BK channels in cerebral arteries underlies hypoperfusion in hypertension-induced vascular dementia

The deficit in cerebral blood flow (CBF) seen in patients with hypertension-induced vascular dementia is increasingly viewed as a therapeutic target for disease-modifying therapy. Progress is limited, however, due to uncertainty surrounding the mechanisms through which elevated blood pressure reduce...

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Detalles Bibliográficos
Autores principales: Taylor, Jade L., Walsh, Katy R., Mosneag, Ioana-Emilia, Danby, Thea G. E., Luka, Nadim, Chanda, Bishal, Schiessl, Ingo, Dunne, Ross A., Hill-Eubanks, David, Hennig, Grant W., Allan, Stuart M., Nelson, Mark T., Greenstein, Adam S., Pritchard, Harry A. T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2023
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10433456/
https://www.ncbi.nlm.nih.gov/pubmed/37549299
http://dx.doi.org/10.1073/pnas.2307513120

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