Efferocytosis of viable versus heat-inactivated MSC induces human monocytes to distinct immunosuppressive phenotypes

BACKGROUND: Immunomodulation by mesenchymal stromal cells (MSCs) can occur through trophic factor mechanisms, however, intravenously infused MSCs are rapidly cleared from the body yet a potent immunotherapeutic response is still observed. Recent work suggests that monocytes contribute to the clearan...

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Detalles Bibliográficos
Autores principales: Schrodt, Michael V., Behan-Bush, Riley M., Liszewski, Jesse N., Humpal-Pash, Madeleine E., Boland, Lauren K., Scroggins, Sabrina M., Santillan, Donna A., Ankrum, James A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10433682/
https://www.ncbi.nlm.nih.gov/pubmed/37592321
http://dx.doi.org/10.1186/s13287-023-03443-z

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