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Preparation of hydroxyapatite nanofibers by using ionic liquids as template and application in enhancing hydrogel performance

Introduction: Hydroxyapatite (HAP or HA) nanofibers are very attractive in the field of biomedical engineering. However, templates used for preparing HAP nanofibers are usually hydrophobic molecules, like fatty acids and/or surfactants, which are difficult to remove and potentially toxic. Therefore,...

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Autores principales: Ren, Xiuli, Liang, Zepeng, Zhao, Xingjun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10433687/
https://www.ncbi.nlm.nih.gov/pubmed/37600302
http://dx.doi.org/10.3389/fbioe.2023.1247448
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author Ren, Xiuli
Liang, Zepeng
Zhao, Xingjun
author_facet Ren, Xiuli
Liang, Zepeng
Zhao, Xingjun
author_sort Ren, Xiuli
collection PubMed
description Introduction: Hydroxyapatite (HAP or HA) nanofibers are very attractive in the field of biomedical engineering. However, templates used for preparing HAP nanofibers are usually hydrophobic molecules, like fatty acids and/or surfactants, which are difficult to remove and potentially toxic. Therefore, it is important to develop a green approach to prepare HAP nanofibers. Methods: Imidazolium-based ionic liquids (ILs) were used as templates to control the crystallization of HAP. The obtained HAP nanofibers were composited into polyvinyl alcohol-sodium alginate (PVA-Alg) hydrogel (HAP@H). The rheological performance, stretching, and compression properties were tested. Scanning electron microscope (SEM), high resolution transmission electron microscope (HRTEM), X-ray diffraction (XRD), Fourier-transform infrared (FT-IR), and differential scanning calorimetry (DSC) were adopted to characterize the morphology, size, crystallographic orientations, and phase of HAP@H. Results: HAP nanofibers with a length of ∼50 μm were harvested. The DSC results proved that water loss temperature increased from 98°C (for pure hydrogel) to 107°C (for HAP@H). Also, HAP@H hydrogel presented much better porous structure, tensile performance, and compressive performance than that of pure hydrogel. Discussion: The morphology, size, and growth direction of HAP could be modulated easily by altering the alkyl chain length of ILs’ cations. This is possibly due to face-specific adsorption of imidazolium moieties on HAP nanocrystals. The enhancing performance of HAP@H is probably due to the composited highly oriented HAP nanofibers.
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spelling pubmed-104336872023-08-18 Preparation of hydroxyapatite nanofibers by using ionic liquids as template and application in enhancing hydrogel performance Ren, Xiuli Liang, Zepeng Zhao, Xingjun Front Bioeng Biotechnol Bioengineering and Biotechnology Introduction: Hydroxyapatite (HAP or HA) nanofibers are very attractive in the field of biomedical engineering. However, templates used for preparing HAP nanofibers are usually hydrophobic molecules, like fatty acids and/or surfactants, which are difficult to remove and potentially toxic. Therefore, it is important to develop a green approach to prepare HAP nanofibers. Methods: Imidazolium-based ionic liquids (ILs) were used as templates to control the crystallization of HAP. The obtained HAP nanofibers were composited into polyvinyl alcohol-sodium alginate (PVA-Alg) hydrogel (HAP@H). The rheological performance, stretching, and compression properties were tested. Scanning electron microscope (SEM), high resolution transmission electron microscope (HRTEM), X-ray diffraction (XRD), Fourier-transform infrared (FT-IR), and differential scanning calorimetry (DSC) were adopted to characterize the morphology, size, crystallographic orientations, and phase of HAP@H. Results: HAP nanofibers with a length of ∼50 μm were harvested. The DSC results proved that water loss temperature increased from 98°C (for pure hydrogel) to 107°C (for HAP@H). Also, HAP@H hydrogel presented much better porous structure, tensile performance, and compressive performance than that of pure hydrogel. Discussion: The morphology, size, and growth direction of HAP could be modulated easily by altering the alkyl chain length of ILs’ cations. This is possibly due to face-specific adsorption of imidazolium moieties on HAP nanocrystals. The enhancing performance of HAP@H is probably due to the composited highly oriented HAP nanofibers. Frontiers Media S.A. 2023-08-02 /pmc/articles/PMC10433687/ /pubmed/37600302 http://dx.doi.org/10.3389/fbioe.2023.1247448 Text en Copyright © 2023 Ren, Liang and Zhao. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Bioengineering and Biotechnology
Ren, Xiuli
Liang, Zepeng
Zhao, Xingjun
Preparation of hydroxyapatite nanofibers by using ionic liquids as template and application in enhancing hydrogel performance
title Preparation of hydroxyapatite nanofibers by using ionic liquids as template and application in enhancing hydrogel performance
title_full Preparation of hydroxyapatite nanofibers by using ionic liquids as template and application in enhancing hydrogel performance
title_fullStr Preparation of hydroxyapatite nanofibers by using ionic liquids as template and application in enhancing hydrogel performance
title_full_unstemmed Preparation of hydroxyapatite nanofibers by using ionic liquids as template and application in enhancing hydrogel performance
title_short Preparation of hydroxyapatite nanofibers by using ionic liquids as template and application in enhancing hydrogel performance
title_sort preparation of hydroxyapatite nanofibers by using ionic liquids as template and application in enhancing hydrogel performance
topic Bioengineering and Biotechnology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10433687/
https://www.ncbi.nlm.nih.gov/pubmed/37600302
http://dx.doi.org/10.3389/fbioe.2023.1247448
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AT zhaoxingjun preparationofhydroxyapatitenanofibersbyusingionicliquidsastemplateandapplicationinenhancinghydrogelperformance