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CHDH, a key mitochondrial enzyme, plays a diagnostic role in metabolic disorders diseases and tumor progression

Human choline dehydrogenase (CHDH) is a transmembrane protein located in mitochondria. CHDH has been shown to be one of the important catalytic enzymes that catalyze the oxidation of choline to betaine and is involved in mitochondrial autophagy after mitochondrial damage. In recent years, an increas...

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Autores principales: Li, Yifei, Shen, Xinzhuang, Yang, Xiaowen, Lian, Fuming, Li, Yanping, Li, Jinmeng, Huang, Yongming, Shen, Wenzhi, Liu, Huan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10433736/
https://www.ncbi.nlm.nih.gov/pubmed/37600654
http://dx.doi.org/10.3389/fgene.2023.1240650
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author Li, Yifei
Shen, Xinzhuang
Yang, Xiaowen
Lian, Fuming
Li, Yanping
Li, Jinmeng
Huang, Yongming
Shen, Wenzhi
Liu, Huan
author_facet Li, Yifei
Shen, Xinzhuang
Yang, Xiaowen
Lian, Fuming
Li, Yanping
Li, Jinmeng
Huang, Yongming
Shen, Wenzhi
Liu, Huan
author_sort Li, Yifei
collection PubMed
description Human choline dehydrogenase (CHDH) is a transmembrane protein located in mitochondria. CHDH has been shown to be one of the important catalytic enzymes that catalyze the oxidation of choline to betaine and is involved in mitochondrial autophagy after mitochondrial damage. In recent years, an increasing number of studies have focused on CHDH and found a close association with the pathogenesis of various diseases, including tumor prognosis. Here we summarized the genomic localization, protein structure and basic functions of CHDH and discuss the progress of CHDH research in metabolic disorders and other diseases. Moreover, we described the regulatory role of CHDH on the progression of different types of malignant tumors. In addition, major pathogenic mechanisms of CHDH in multiple diseases may be associated with single nucleotide polymorphism (SNP). We look forward to providing new strategies and basis for clinical diagnosis and prognosis prediction of diseases by diagnosing SNP loci of CHDH genes. Our work evaluates the feasibility of CHDH as a molecular marker relevant to the diagnosis of some metabolic disorders diseases and tumors, which may provide new targets for the treatment of related diseases and tumors.
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spelling pubmed-104337362023-08-18 CHDH, a key mitochondrial enzyme, plays a diagnostic role in metabolic disorders diseases and tumor progression Li, Yifei Shen, Xinzhuang Yang, Xiaowen Lian, Fuming Li, Yanping Li, Jinmeng Huang, Yongming Shen, Wenzhi Liu, Huan Front Genet Genetics Human choline dehydrogenase (CHDH) is a transmembrane protein located in mitochondria. CHDH has been shown to be one of the important catalytic enzymes that catalyze the oxidation of choline to betaine and is involved in mitochondrial autophagy after mitochondrial damage. In recent years, an increasing number of studies have focused on CHDH and found a close association with the pathogenesis of various diseases, including tumor prognosis. Here we summarized the genomic localization, protein structure and basic functions of CHDH and discuss the progress of CHDH research in metabolic disorders and other diseases. Moreover, we described the regulatory role of CHDH on the progression of different types of malignant tumors. In addition, major pathogenic mechanisms of CHDH in multiple diseases may be associated with single nucleotide polymorphism (SNP). We look forward to providing new strategies and basis for clinical diagnosis and prognosis prediction of diseases by diagnosing SNP loci of CHDH genes. Our work evaluates the feasibility of CHDH as a molecular marker relevant to the diagnosis of some metabolic disorders diseases and tumors, which may provide new targets for the treatment of related diseases and tumors. Frontiers Media S.A. 2023-08-02 /pmc/articles/PMC10433736/ /pubmed/37600654 http://dx.doi.org/10.3389/fgene.2023.1240650 Text en Copyright © 2023 Li, Shen, Yang, Lian, Li, Li, Huang, Shen and Liu. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Genetics
Li, Yifei
Shen, Xinzhuang
Yang, Xiaowen
Lian, Fuming
Li, Yanping
Li, Jinmeng
Huang, Yongming
Shen, Wenzhi
Liu, Huan
CHDH, a key mitochondrial enzyme, plays a diagnostic role in metabolic disorders diseases and tumor progression
title CHDH, a key mitochondrial enzyme, plays a diagnostic role in metabolic disorders diseases and tumor progression
title_full CHDH, a key mitochondrial enzyme, plays a diagnostic role in metabolic disorders diseases and tumor progression
title_fullStr CHDH, a key mitochondrial enzyme, plays a diagnostic role in metabolic disorders diseases and tumor progression
title_full_unstemmed CHDH, a key mitochondrial enzyme, plays a diagnostic role in metabolic disorders diseases and tumor progression
title_short CHDH, a key mitochondrial enzyme, plays a diagnostic role in metabolic disorders diseases and tumor progression
title_sort chdh, a key mitochondrial enzyme, plays a diagnostic role in metabolic disorders diseases and tumor progression
topic Genetics
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10433736/
https://www.ncbi.nlm.nih.gov/pubmed/37600654
http://dx.doi.org/10.3389/fgene.2023.1240650
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