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Apolipoprotein E isoform does not influence trans-synaptic spread of tau pathology in a mouse model

A key hallmark of Alzheimer’s disease (AD) is the accumulation of hyperphosphorylated tau in neurofibrillary tangles. This occurs alongside neuroinflammation and neurodegeneration. Pathological tau propagates through the AD brain in a defined manner, which correlates with neuron and synapse loss and...

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Detalles Bibliográficos
Autores principales:	Davies, Caitlin, Tulloch, Jane, Yip, Ellie, Currie, Lydia, Colom-Cadena, Marti, Wegmann, Susanne, Hyman, Bradley T, Wilkins, Lewis, Hooley, Monique, Tzioras, Makis, Spires-Jones, Tara L
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	SAGE Publications 2023
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10433884/ https://www.ncbi.nlm.nih.gov/pubmed/37600228 http://dx.doi.org/10.1177/23982128231191046

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