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Lipid A Modification and Metabolic Adaptation in Polymyxin-Resistant, New Delhi Metallo-β-Lactamase–Producing Klebsiella pneumoniae

Polymyxins are last-line antibiotics employed against multidrug-resistant (MDR) Klebsiella pneumoniae. Worryingly, polymyxin resistance is rapidly on the rise globally. Polymyxins initially target lipid A of lipopolysaccharides (LPSs) in the cell outer membrane (OM), causing disorganization and cell...

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Detalles Bibliográficos
Autores principales:	Lu, Jing, Han, Meiling, Yu, Heidi H., Bergen, Phillip J., Liu, Yiyun, Zhao, Jinxin, Wickremasinghe, Hasini, Jiang, Xukai, Hu, Yang, Du, Haiyan, Zhu, Yan, Velkov, Tony
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Microbiology 2023
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10433984/ https://www.ncbi.nlm.nih.gov/pubmed/37432123 http://dx.doi.org/10.1128/spectrum.00852-23

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