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Suicidality in Treatment-Resistant Depression Patients
INTRODUCTION: Depression and treatment-resistant depression (RD) are associated with suicidal behavior (SB) at a higher rate. OBJECTIVES: 1) determination prevalence of RD in district outpatient psychiatric сlinics (i.e., dispensaries) and the socio-demographic characteristics of RD patients with SB...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Cambridge University Press
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10434094/ http://dx.doi.org/10.1192/j.eurpsy.2023.704 |
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author | Lyubov, E. B. Semenova, N. D. |
author_facet | Lyubov, E. B. Semenova, N. D. |
author_sort | Lyubov, E. B. |
collection | PubMed |
description | INTRODUCTION: Depression and treatment-resistant depression (RD) are associated with suicidal behavior (SB) at a higher rate. OBJECTIVES: 1) determination prevalence of RD in district outpatient psychiatric сlinics (i.e., dispensaries) and the socio-demographic characteristics of RD patients with SB. METHODS: In this multicenter (3 sites), retrospective, observational epidemiological study, patients (n=148) with diagnoses F 30-39 (ICD-10) were recruited in 2020. Patients (n=22) were assessed for RD, defined as failure to respond to ≥ two antidepressant medications of adequate dose and duration for at least three months. RESULTS: The prevalence of depression is ≤ 2% of the outpatient population. RD prevalence ˜15%. SB (i.e., suicidal attempts) was noted in every fifth (n=5) for the index year. SB patients differed in the following typical features: a woman (82%) mean age, 46.8 years with long-term (≥ 10 years) depression and annual hospitalizations for three years (61.4 days per patient), and with suicidal attempts (repeated within the last two years) through (80%) self-poisoning with psychotropic drugs. Nobоdy worked, and everyone was divorced. CONCLUSIONS: On the background of ubiquitous underdiagnosis of depressive disorders in routine practice, RD patients with SP represent a high-resource users group with combined clinical and social problems requiring pharmacotherapy and target psychosocial rehabilitation. DISCLOSURE OF INTEREST: None Declared |
format | Online Article Text |
id | pubmed-10434094 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Cambridge University Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-104340942023-08-18 Suicidality in Treatment-Resistant Depression Patients Lyubov, E. B. Semenova, N. D. Eur Psychiatry Abstract INTRODUCTION: Depression and treatment-resistant depression (RD) are associated with suicidal behavior (SB) at a higher rate. OBJECTIVES: 1) determination prevalence of RD in district outpatient psychiatric сlinics (i.e., dispensaries) and the socio-demographic characteristics of RD patients with SB. METHODS: In this multicenter (3 sites), retrospective, observational epidemiological study, patients (n=148) with diagnoses F 30-39 (ICD-10) were recruited in 2020. Patients (n=22) were assessed for RD, defined as failure to respond to ≥ two antidepressant medications of adequate dose and duration for at least three months. RESULTS: The prevalence of depression is ≤ 2% of the outpatient population. RD prevalence ˜15%. SB (i.e., suicidal attempts) was noted in every fifth (n=5) for the index year. SB patients differed in the following typical features: a woman (82%) mean age, 46.8 years with long-term (≥ 10 years) depression and annual hospitalizations for three years (61.4 days per patient), and with suicidal attempts (repeated within the last two years) through (80%) self-poisoning with psychotropic drugs. Nobоdy worked, and everyone was divorced. CONCLUSIONS: On the background of ubiquitous underdiagnosis of depressive disorders in routine practice, RD patients with SP represent a high-resource users group with combined clinical and social problems requiring pharmacotherapy and target psychosocial rehabilitation. DISCLOSURE OF INTEREST: None Declared Cambridge University Press 2023-07-19 /pmc/articles/PMC10434094/ http://dx.doi.org/10.1192/j.eurpsy.2023.704 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted re-use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Abstract Lyubov, E. B. Semenova, N. D. Suicidality in Treatment-Resistant Depression Patients |
title | Suicidality in Treatment-Resistant Depression Patients |
title_full | Suicidality in Treatment-Resistant Depression Patients |
title_fullStr | Suicidality in Treatment-Resistant Depression Patients |
title_full_unstemmed | Suicidality in Treatment-Resistant Depression Patients |
title_short | Suicidality in Treatment-Resistant Depression Patients |
title_sort | suicidality in treatment-resistant depression patients |
topic | Abstract |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10434094/ http://dx.doi.org/10.1192/j.eurpsy.2023.704 |
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