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Reduced Susceptibility to Azoles in Cryptococcus gattii Correlates with the Substitution R258L in a Substrate Recognition Site of the Lanosterol 14-α-Demethylase

Cryptococcus neoformans and Cryptococcus gattii cause cryptococcosis, a life-threatening fungal infection affecting mostly immunocompromised patients. In fact, cryptococcal meningitis accounts for about 19% of AIDS-related deaths in the world. Because of long-term azole therapies to treat this mycos...

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Detalles Bibliográficos
Autores principales:	Carvajal, Silvia Katherine, Melendres, Javier, Escandón, Patricia, Firacative, Carolina
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Microbiology 2023
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10434158/ https://www.ncbi.nlm.nih.gov/pubmed/37341584 http://dx.doi.org/10.1128/spectrum.01403-23

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