An Endogenous Staphylococcus aureus CRISPR-Cas System Limits Phage Proliferation and Is Efficiently Excised from the Genome as Part of the SCCmec Cassette

CRISPR-Cas is an adaptive immune system that allows bacteria to inactivate mobile genetic elements. Approximately 50% of bacteria harbor CRISPR-Cas; however, in the human pathogen Staphylococcus aureus, CRISPR-Cas loci are less common and often studied in heterologous systems. We analyzed the preval...

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Detalles Bibliográficos
Autores principales: Mikkelsen, Kasper, Bowring, Janine Zara, Ng, Yong Kai, Svanberg Frisinger, Frida, Maglegaard, Julie Kjærsgaard, Li, Qiuchun, Sieber, Raphael N., Petersen, Andreas, Andersen, Paal Skytt, Rostøl, Jakob T., Høyland-Kroghsbo, Nina Molin, Ingmer, Hanne
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10434264/
https://www.ncbi.nlm.nih.gov/pubmed/37404143
http://dx.doi.org/10.1128/spectrum.01277-23

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