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Case report: Effect of Hb E heterozygosity on HbA1c value by the Tosoh HLC-723G11
OBJECTIVE: We report the effect of Hb E heterozygosity on HbA1c value by the Tosoh HLC-723G11. CASE REPORT: A 45 years-old Chinese woman presented with an abnormally low HbA1c level of 3.7% (3.9%–6.1%) in a health examination. Fasting blood glucose was normal. Blood routine examination and serum bil...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10434524/ https://www.ncbi.nlm.nih.gov/pubmed/37601204 http://dx.doi.org/10.3389/fpubh.2023.1217662 |
Sumario: | OBJECTIVE: We report the effect of Hb E heterozygosity on HbA1c value by the Tosoh HLC-723G11. CASE REPORT: A 45 years-old Chinese woman presented with an abnormally low HbA1c level of 3.7% (3.9%–6.1%) in a health examination. Fasting blood glucose was normal. Blood routine examination and serum bilirubin were in the normal range. HbA1c was determined by Tosoh HLC-723G11. There was an abnormal peak between A1c and A0 on the chromatogram. Hemoglobin electrophoresis indicated that the Hb E zone accounted for 25.1%. The β-thalassemia-related genes (mutant type) were βE M/N, and the related gene CD26 (A > G) was mutated. OGTT indicated prediabetes. CONCLUSION: Hb E heterozygosity may reduce HbA1c value with abnormal chromatograms, as determined by a Tosoh HLC G11 analyzer. The Tosoh HLC G11 analyzer can well identify Hb E variation. In this case, further blood glucose-related tests should be performed to avoid missed diagnoses. However, a large sample size is needed to confirm this conclusion. |
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