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Case report: Effect of Hb E heterozygosity on HbA1c value by the Tosoh HLC-723G11
OBJECTIVE: We report the effect of Hb E heterozygosity on HbA1c value by the Tosoh HLC-723G11. CASE REPORT: A 45 years-old Chinese woman presented with an abnormally low HbA1c level of 3.7% (3.9%–6.1%) in a health examination. Fasting blood glucose was normal. Blood routine examination and serum bil...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10434524/ https://www.ncbi.nlm.nih.gov/pubmed/37601204 http://dx.doi.org/10.3389/fpubh.2023.1217662 |
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author | Gao, Wei Li, Wenyu Zheng, Qian Jiang, Nenggang Tang, Huairong |
author_facet | Gao, Wei Li, Wenyu Zheng, Qian Jiang, Nenggang Tang, Huairong |
author_sort | Gao, Wei |
collection | PubMed |
description | OBJECTIVE: We report the effect of Hb E heterozygosity on HbA1c value by the Tosoh HLC-723G11. CASE REPORT: A 45 years-old Chinese woman presented with an abnormally low HbA1c level of 3.7% (3.9%–6.1%) in a health examination. Fasting blood glucose was normal. Blood routine examination and serum bilirubin were in the normal range. HbA1c was determined by Tosoh HLC-723G11. There was an abnormal peak between A1c and A0 on the chromatogram. Hemoglobin electrophoresis indicated that the Hb E zone accounted for 25.1%. The β-thalassemia-related genes (mutant type) were βE M/N, and the related gene CD26 (A > G) was mutated. OGTT indicated prediabetes. CONCLUSION: Hb E heterozygosity may reduce HbA1c value with abnormal chromatograms, as determined by a Tosoh HLC G11 analyzer. The Tosoh HLC G11 analyzer can well identify Hb E variation. In this case, further blood glucose-related tests should be performed to avoid missed diagnoses. However, a large sample size is needed to confirm this conclusion. |
format | Online Article Text |
id | pubmed-10434524 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-104345242023-08-18 Case report: Effect of Hb E heterozygosity on HbA1c value by the Tosoh HLC-723G11 Gao, Wei Li, Wenyu Zheng, Qian Jiang, Nenggang Tang, Huairong Front Public Health Public Health OBJECTIVE: We report the effect of Hb E heterozygosity on HbA1c value by the Tosoh HLC-723G11. CASE REPORT: A 45 years-old Chinese woman presented with an abnormally low HbA1c level of 3.7% (3.9%–6.1%) in a health examination. Fasting blood glucose was normal. Blood routine examination and serum bilirubin were in the normal range. HbA1c was determined by Tosoh HLC-723G11. There was an abnormal peak between A1c and A0 on the chromatogram. Hemoglobin electrophoresis indicated that the Hb E zone accounted for 25.1%. The β-thalassemia-related genes (mutant type) were βE M/N, and the related gene CD26 (A > G) was mutated. OGTT indicated prediabetes. CONCLUSION: Hb E heterozygosity may reduce HbA1c value with abnormal chromatograms, as determined by a Tosoh HLC G11 analyzer. The Tosoh HLC G11 analyzer can well identify Hb E variation. In this case, further blood glucose-related tests should be performed to avoid missed diagnoses. However, a large sample size is needed to confirm this conclusion. Frontiers Media S.A. 2023-08-03 /pmc/articles/PMC10434524/ /pubmed/37601204 http://dx.doi.org/10.3389/fpubh.2023.1217662 Text en Copyright © 2023 Gao, Li, Zheng, Jiang and Tang. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Public Health Gao, Wei Li, Wenyu Zheng, Qian Jiang, Nenggang Tang, Huairong Case report: Effect of Hb E heterozygosity on HbA1c value by the Tosoh HLC-723G11 |
title | Case report: Effect of Hb E heterozygosity on HbA1c value by the Tosoh HLC-723G11 |
title_full | Case report: Effect of Hb E heterozygosity on HbA1c value by the Tosoh HLC-723G11 |
title_fullStr | Case report: Effect of Hb E heterozygosity on HbA1c value by the Tosoh HLC-723G11 |
title_full_unstemmed | Case report: Effect of Hb E heterozygosity on HbA1c value by the Tosoh HLC-723G11 |
title_short | Case report: Effect of Hb E heterozygosity on HbA1c value by the Tosoh HLC-723G11 |
title_sort | case report: effect of hb e heterozygosity on hba1c value by the tosoh hlc-723g11 |
topic | Public Health |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10434524/ https://www.ncbi.nlm.nih.gov/pubmed/37601204 http://dx.doi.org/10.3389/fpubh.2023.1217662 |
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