Cargando…
Post-translational modifications and protein quality control of mitochondrial channels and transporters
Mitochondria play a critical role in energy metabolism and signal transduction, which is tightly regulated by proteins, metabolites, and ion fluxes. Metabolites and ion homeostasis are mainly mediated by channels and transporters present on mitochondrial membranes. Mitochondria comprise two distinct...
Autores principales: | , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2023
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10434574/ https://www.ncbi.nlm.nih.gov/pubmed/37601094 http://dx.doi.org/10.3389/fcell.2023.1196466 |
_version_ | 1785091925983887360 |
---|---|
author | Kadam, Ashlesha Jadiya, Pooja Tomar, Dhanendra |
author_facet | Kadam, Ashlesha Jadiya, Pooja Tomar, Dhanendra |
author_sort | Kadam, Ashlesha |
collection | PubMed |
description | Mitochondria play a critical role in energy metabolism and signal transduction, which is tightly regulated by proteins, metabolites, and ion fluxes. Metabolites and ion homeostasis are mainly mediated by channels and transporters present on mitochondrial membranes. Mitochondria comprise two distinct compartments, the outer mitochondrial membrane (OMM) and the inner mitochondrial membrane (IMM), which have differing permeabilities to ions and metabolites. The OMM is semipermeable due to the presence of non-selective molecular pores, while the IMM is highly selective and impermeable due to the presence of specialized channels and transporters which regulate ion and metabolite fluxes. These channels and transporters are modulated by various post-translational modifications (PTMs), including phosphorylation, oxidative modifications, ions, and metabolites binding, glycosylation, acetylation, and others. Additionally, the mitochondrial protein quality control (MPQC) system plays a crucial role in ensuring efficient molecular flux through the mitochondrial membranes by selectively removing mistargeted or defective proteins. Inefficient functioning of the transporters and channels in mitochondria can disrupt cellular homeostasis, leading to the onset of various pathological conditions. In this review, we provide a comprehensive overview of the current understanding of mitochondrial channels and transporters in terms of their functions, PTMs, and quality control mechanisms. |
format | Online Article Text |
id | pubmed-10434574 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-104345742023-08-18 Post-translational modifications and protein quality control of mitochondrial channels and transporters Kadam, Ashlesha Jadiya, Pooja Tomar, Dhanendra Front Cell Dev Biol Cell and Developmental Biology Mitochondria play a critical role in energy metabolism and signal transduction, which is tightly regulated by proteins, metabolites, and ion fluxes. Metabolites and ion homeostasis are mainly mediated by channels and transporters present on mitochondrial membranes. Mitochondria comprise two distinct compartments, the outer mitochondrial membrane (OMM) and the inner mitochondrial membrane (IMM), which have differing permeabilities to ions and metabolites. The OMM is semipermeable due to the presence of non-selective molecular pores, while the IMM is highly selective and impermeable due to the presence of specialized channels and transporters which regulate ion and metabolite fluxes. These channels and transporters are modulated by various post-translational modifications (PTMs), including phosphorylation, oxidative modifications, ions, and metabolites binding, glycosylation, acetylation, and others. Additionally, the mitochondrial protein quality control (MPQC) system plays a crucial role in ensuring efficient molecular flux through the mitochondrial membranes by selectively removing mistargeted or defective proteins. Inefficient functioning of the transporters and channels in mitochondria can disrupt cellular homeostasis, leading to the onset of various pathological conditions. In this review, we provide a comprehensive overview of the current understanding of mitochondrial channels and transporters in terms of their functions, PTMs, and quality control mechanisms. Frontiers Media S.A. 2023-08-03 /pmc/articles/PMC10434574/ /pubmed/37601094 http://dx.doi.org/10.3389/fcell.2023.1196466 Text en Copyright © 2023 Kadam, Jadiya and Tomar. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Cell and Developmental Biology Kadam, Ashlesha Jadiya, Pooja Tomar, Dhanendra Post-translational modifications and protein quality control of mitochondrial channels and transporters |
title | Post-translational modifications and protein quality control of mitochondrial channels and transporters |
title_full | Post-translational modifications and protein quality control of mitochondrial channels and transporters |
title_fullStr | Post-translational modifications and protein quality control of mitochondrial channels and transporters |
title_full_unstemmed | Post-translational modifications and protein quality control of mitochondrial channels and transporters |
title_short | Post-translational modifications and protein quality control of mitochondrial channels and transporters |
title_sort | post-translational modifications and protein quality control of mitochondrial channels and transporters |
topic | Cell and Developmental Biology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10434574/ https://www.ncbi.nlm.nih.gov/pubmed/37601094 http://dx.doi.org/10.3389/fcell.2023.1196466 |
work_keys_str_mv | AT kadamashlesha posttranslationalmodificationsandproteinqualitycontrolofmitochondrialchannelsandtransporters AT jadiyapooja posttranslationalmodificationsandproteinqualitycontrolofmitochondrialchannelsandtransporters AT tomardhanendra posttranslationalmodificationsandproteinqualitycontrolofmitochondrialchannelsandtransporters |