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New insights into cerebellar dysfunction in patients with delusional disorder: A systematic review

INTRODUCTION: The cerebellum has been implicated in cognitive, affective and motor functions, including emotion regulation, executive control and sensorimotor processing. In schizophrenia, cerebellar dysfunction has been associated with treatment resistance and clinical features. However, few studie...

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Autores principales: González- Rodríguez, A., Guàrdia, A., Alvarez, A., Natividad, M., Pagés, C., Ghigliazza, C., Román, E., Sánchez, B., Monreal, J. A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cambridge University Press 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10434618/
http://dx.doi.org/10.1192/j.eurpsy.2023.808
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author González- Rodríguez, A.
Guàrdia, A.
Alvarez, A.
Natividad, M.
Pagés, C.
Ghigliazza, C.
Román, E.
Sánchez, B.
Monreal, J. A.
author_facet González- Rodríguez, A.
Guàrdia, A.
Alvarez, A.
Natividad, M.
Pagés, C.
Ghigliazza, C.
Román, E.
Sánchez, B.
Monreal, J. A.
author_sort González- Rodríguez, A.
collection PubMed
description INTRODUCTION: The cerebellum has been implicated in cognitive, affective and motor functions, including emotion regulation, executive control and sensorimotor processing. In schizophrenia, cerebellar dysfunction has been associated with treatment resistance and clinical features. However, few studies have been focused on delusional disorder (DD). OBJECTIVES: Our main purpose was to review the evidence available on cerebellum abnormalities and dysfunctions in patients with DD. METHODS: A systematic review was conducted through PubMed, Scopus and ClinicalTrials.gov (inception-June 2022) according to the Preferred Reporting Items for Systematic Reviews and Meta-analyses (PRISMA) directives. The following search terms were used: cerebellum OR cerebellar AND (“delusional disorder” AND paranoia). Reference lists from included studies were hand-checked to find other potential relevant papers. RESULTS: Six studies were included from a total of 119 retrieved records (PubMed: 52, Scopus: 66, ClinicalTrials.gov: 1). Study 1:Patients with DD somatic type (n=14) presented a decreased gray matter volume in cerebellar lobules compared to healthy controls (HC) (n=32, left lobule VIIIa) and non-somatic DD (n=18, lobule V). Cerebellar volumes did not seem to differ between HC and non-somatic DD. Study 2:Abnormalities of voluntary saccadic eye movements, linking frontal and cerebellar functions, were found in DD patients (n=34) compared to HC (n=40). Study 3: Abnormal smooth pursuit eye movements in DD (n=15) compared with HC (n=40) and similar to schizophrenia (n=40). Case reports (n=3): DD associated with Dandy-Walker variant (partial vermian hypoplasia), unruptured intracerebral aneurysm of basilar artery, and megacisterna magna. CONCLUSIONS: Cerebellar deficits in patients with DD has been reported, particularly in those presenting somatic delusional contents. DISCLOSURE OF INTEREST: None Declared
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spelling pubmed-104346182023-08-18 New insights into cerebellar dysfunction in patients with delusional disorder: A systematic review González- Rodríguez, A. Guàrdia, A. Alvarez, A. Natividad, M. Pagés, C. Ghigliazza, C. Román, E. Sánchez, B. Monreal, J. A. Eur Psychiatry Abstract INTRODUCTION: The cerebellum has been implicated in cognitive, affective and motor functions, including emotion regulation, executive control and sensorimotor processing. In schizophrenia, cerebellar dysfunction has been associated with treatment resistance and clinical features. However, few studies have been focused on delusional disorder (DD). OBJECTIVES: Our main purpose was to review the evidence available on cerebellum abnormalities and dysfunctions in patients with DD. METHODS: A systematic review was conducted through PubMed, Scopus and ClinicalTrials.gov (inception-June 2022) according to the Preferred Reporting Items for Systematic Reviews and Meta-analyses (PRISMA) directives. The following search terms were used: cerebellum OR cerebellar AND (“delusional disorder” AND paranoia). Reference lists from included studies were hand-checked to find other potential relevant papers. RESULTS: Six studies were included from a total of 119 retrieved records (PubMed: 52, Scopus: 66, ClinicalTrials.gov: 1). Study 1:Patients with DD somatic type (n=14) presented a decreased gray matter volume in cerebellar lobules compared to healthy controls (HC) (n=32, left lobule VIIIa) and non-somatic DD (n=18, lobule V). Cerebellar volumes did not seem to differ between HC and non-somatic DD. Study 2:Abnormalities of voluntary saccadic eye movements, linking frontal and cerebellar functions, were found in DD patients (n=34) compared to HC (n=40). Study 3: Abnormal smooth pursuit eye movements in DD (n=15) compared with HC (n=40) and similar to schizophrenia (n=40). Case reports (n=3): DD associated with Dandy-Walker variant (partial vermian hypoplasia), unruptured intracerebral aneurysm of basilar artery, and megacisterna magna. CONCLUSIONS: Cerebellar deficits in patients with DD has been reported, particularly in those presenting somatic delusional contents. DISCLOSURE OF INTEREST: None Declared Cambridge University Press 2023-07-19 /pmc/articles/PMC10434618/ http://dx.doi.org/10.1192/j.eurpsy.2023.808 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted re-use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Abstract
González- Rodríguez, A.
Guàrdia, A.
Alvarez, A.
Natividad, M.
Pagés, C.
Ghigliazza, C.
Román, E.
Sánchez, B.
Monreal, J. A.
New insights into cerebellar dysfunction in patients with delusional disorder: A systematic review
title New insights into cerebellar dysfunction in patients with delusional disorder: A systematic review
title_full New insights into cerebellar dysfunction in patients with delusional disorder: A systematic review
title_fullStr New insights into cerebellar dysfunction in patients with delusional disorder: A systematic review
title_full_unstemmed New insights into cerebellar dysfunction in patients with delusional disorder: A systematic review
title_short New insights into cerebellar dysfunction in patients with delusional disorder: A systematic review
title_sort new insights into cerebellar dysfunction in patients with delusional disorder: a systematic review
topic Abstract
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10434618/
http://dx.doi.org/10.1192/j.eurpsy.2023.808
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