Cargando…

The emergence of Omicron VOC and its rapid spread and persistence in the Western Amazon

Genomic surveillance represents a strategy to understanding the evolutionary mechanisms, transmission, and infectivity of different SARS-CoV-2 variants. We evaluated 603 individuals positive for SARS-CoV-2 from 34 municipalities of Rondônia between December 2021 to December 2022. Nasopharyngeal samp...

Descripción completa

Detalles Bibliográficos
Autores principales: Sgorlon, Gabriella, Roca, Tárcio P., Passos-Silva, Ana Maisa, Queiroz, Jackson A. S., Teixeira, Karolaine S., Araújo, Adrhyan, Batista, Flávia S., Souza, Valquiria R., Oliveira, Franciane M., Morello, Luis G., Marchini, Fabricio K., Salcedo, Juan M.V., Rampazzo, Rita de Cassia P., Naveca, Felipe G., Vieira, Deusilene
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10434903/
https://www.ncbi.nlm.nih.gov/pubmed/37590264
http://dx.doi.org/10.1371/journal.pone.0285742
Descripción
Sumario:Genomic surveillance represents a strategy to understanding the evolutionary mechanisms, transmission, and infectivity of different SARS-CoV-2 variants. We evaluated 603 individuals positive for SARS-CoV-2 from 34 municipalities of Rondônia between December 2021 to December 2022. Nasopharyngeal samples were collected, RNA was extracted and screened using RT-qPCR for VOCs. RNA of the samples were sequenced and further analyzed for phylogeny, mutations, and lineages, totaling 96.19% of samples positive for Omicron VOC in this cohort. We observed that most individuals had at least two doses, however 18.97% were not vaccinated with any dose. 554 sequences were amenable to analysis for alignment and phylogenetic characterization; this group corresponded to the 27 subvariants of the Omicron VOC; a total of 100 mutations were identified, 48% of which were found in the S gene. In conclusion, the data demonstrated the rapid spread and persistence of Omicron VOC in Rondônia during the 12-month study period. Although high frequency of mutations was found in the analyzed samples, there were no individuals with a severe clinical profile, demonstrating that vaccination had a positive effect in those cases.