Post-infection treatment with the E protein inhibitor BIT225 reduces disease severity and increases survival of K18-hACE2 transgenic mice infected with a lethal dose of SARS-CoV-2

The Coronavirus envelope (E) protein is a small structural protein with ion channel activity that plays an important role in virus assembly, budding, immunopathogenesis and disease severity. The viroporin E is also located in Golgi and ER membranes of infected cells and is associated with inflammaso...

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Detalles Bibliográficos
Autores principales: Ewart, Gary, Bobardt, Michael, Bentzen, Bo Hjorth, Yan, Yannan, Thomson, Audrey, Klumpp, Klaus, Becker, Stephen, Rosenkilde, Mette M., Miller, Michelle, Gallay, Philippe
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10434922/
https://www.ncbi.nlm.nih.gov/pubmed/37549173
http://dx.doi.org/10.1371/journal.ppat.1011328

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