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Poor Access to Liver Transplantation and Survival of Children With Acute Liver Failure, Acute-on-chronic Liver Failure or Chronic Liver Disease

We describe the survival of children with acute liver failure (ALF), chronic liver disease (CLD), or acute-on-chronic liver failure (ACLF) with poor access to liver transplantation (LT). A retrospective cohort study of 42 patients <18 years of age was conducted in the Hospital Civil de Guadalajar...

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Autores principales: Estrada-Arce, Emma Valeria, Aguila-Cano, Renata, Lona-Reyes, Juan Carlos, Flores-Fong, Laura Esther, Rivera-Chávez, Elva
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Lippincott Williams & Wilkins, Inc. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10435031/
https://www.ncbi.nlm.nih.gov/pubmed/37600617
http://dx.doi.org/10.1097/PG9.0000000000000318
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author Estrada-Arce, Emma Valeria
Aguila-Cano, Renata
Lona-Reyes, Juan Carlos
Flores-Fong, Laura Esther
Rivera-Chávez, Elva
author_facet Estrada-Arce, Emma Valeria
Aguila-Cano, Renata
Lona-Reyes, Juan Carlos
Flores-Fong, Laura Esther
Rivera-Chávez, Elva
author_sort Estrada-Arce, Emma Valeria
collection PubMed
description We describe the survival of children with acute liver failure (ALF), chronic liver disease (CLD), or acute-on-chronic liver failure (ACLF) with poor access to liver transplantation (LT). A retrospective cohort study of 42 patients <18 years of age was conducted in the Hospital Civil de Guadalajara “Dr. Juan I. Menchaca”. The median age was 76 months; 57.1% were female, 40.5% presented with ALF, 35.7% with CLD, and 23.8% with ACLF. Also, 38.1% (16/42) presented liver disease of unknown etiology. Death occurred in 45.2%; 14.3% were transferred to another hospital, and none received LT. Mortality in ALF, CLD, and ACLF was 76%, 0%, and 60%, respectively. In the survival analysis, within the first 20 months after diagnosis, the mortality rate was greater than 50% with ALF. The importance of having referral programs that perform liver transplantation is highlighted by the poor prognosis of the patients, despite conservative treatment.
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spelling pubmed-104350312023-08-18 Poor Access to Liver Transplantation and Survival of Children With Acute Liver Failure, Acute-on-chronic Liver Failure or Chronic Liver Disease Estrada-Arce, Emma Valeria Aguila-Cano, Renata Lona-Reyes, Juan Carlos Flores-Fong, Laura Esther Rivera-Chávez, Elva JPGN Rep Brief Report We describe the survival of children with acute liver failure (ALF), chronic liver disease (CLD), or acute-on-chronic liver failure (ACLF) with poor access to liver transplantation (LT). A retrospective cohort study of 42 patients <18 years of age was conducted in the Hospital Civil de Guadalajara “Dr. Juan I. Menchaca”. The median age was 76 months; 57.1% were female, 40.5% presented with ALF, 35.7% with CLD, and 23.8% with ACLF. Also, 38.1% (16/42) presented liver disease of unknown etiology. Death occurred in 45.2%; 14.3% were transferred to another hospital, and none received LT. Mortality in ALF, CLD, and ACLF was 76%, 0%, and 60%, respectively. In the survival analysis, within the first 20 months after diagnosis, the mortality rate was greater than 50% with ALF. The importance of having referral programs that perform liver transplantation is highlighted by the poor prognosis of the patients, despite conservative treatment. Lippincott Williams & Wilkins, Inc. 2023-06-09 /pmc/articles/PMC10435031/ /pubmed/37600617 http://dx.doi.org/10.1097/PG9.0000000000000318 Text en Copyright © 2023 The Author(s). Published by Wolters Kluwer Health, Inc. on behalf of the European Society for Pediatric Gastroenterology, Hepatology, and Nutrition and the North American Society for Pediatric Gastroenterology, Hepatology, and Nutrition. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the Creative Commons Attribution License 4.0 (CCBY (https://creativecommons.org/licenses/by/4.0/) ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Brief Report
Estrada-Arce, Emma Valeria
Aguila-Cano, Renata
Lona-Reyes, Juan Carlos
Flores-Fong, Laura Esther
Rivera-Chávez, Elva
Poor Access to Liver Transplantation and Survival of Children With Acute Liver Failure, Acute-on-chronic Liver Failure or Chronic Liver Disease
title Poor Access to Liver Transplantation and Survival of Children With Acute Liver Failure, Acute-on-chronic Liver Failure or Chronic Liver Disease
title_full Poor Access to Liver Transplantation and Survival of Children With Acute Liver Failure, Acute-on-chronic Liver Failure or Chronic Liver Disease
title_fullStr Poor Access to Liver Transplantation and Survival of Children With Acute Liver Failure, Acute-on-chronic Liver Failure or Chronic Liver Disease
title_full_unstemmed Poor Access to Liver Transplantation and Survival of Children With Acute Liver Failure, Acute-on-chronic Liver Failure or Chronic Liver Disease
title_short Poor Access to Liver Transplantation and Survival of Children With Acute Liver Failure, Acute-on-chronic Liver Failure or Chronic Liver Disease
title_sort poor access to liver transplantation and survival of children with acute liver failure, acute-on-chronic liver failure or chronic liver disease
topic Brief Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10435031/
https://www.ncbi.nlm.nih.gov/pubmed/37600617
http://dx.doi.org/10.1097/PG9.0000000000000318
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