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The past and present of therapeutic strategy for Alzheimer’s diseases: potential for stem cell therapy

Alzheimer’s disease (AD), a progressive neurodegenerative disease characterized by cognitive dysfunction and neuropsychiatric symptoms, is the most prevalent form of dementia among the elderly. Amyloid aggregation, tau hyperphosphorylation, and neural cell loss are the main pathological features. Va...

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Autor principal: Murayama, Masanori A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Japanese Association for Laboratory Animal Science 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10435354/
https://www.ncbi.nlm.nih.gov/pubmed/36878603
http://dx.doi.org/10.1538/expanim.22-0164
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author Murayama, Masanori A.
author_facet Murayama, Masanori A.
author_sort Murayama, Masanori A.
collection PubMed
description Alzheimer’s disease (AD), a progressive neurodegenerative disease characterized by cognitive dysfunction and neuropsychiatric symptoms, is the most prevalent form of dementia among the elderly. Amyloid aggregation, tau hyperphosphorylation, and neural cell loss are the main pathological features. Various hypotheses have been proposed to explain the development of AD. Some therapeutic agents have shown clinical benefits in patients with AD; however, many of these agents have failed. The degree of neural cell loss is associated with the severity of AD. Adult neurogenesis, which governs cognitive and emotional behaviors, occurs in the hippocampus, and some research groups have reported that neural cell transplantation into the hippocampus improves cognitive dysfunction in AD model mice. Based on these clinical findings, stem cell therapy for patients with AD has recently attracted attention. This review provides past and present therapeutic strategies for the management and treatment of AD.
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spelling pubmed-104353542023-08-19 The past and present of therapeutic strategy for Alzheimer’s diseases: potential for stem cell therapy Murayama, Masanori A. Exp Anim Review Alzheimer’s disease (AD), a progressive neurodegenerative disease characterized by cognitive dysfunction and neuropsychiatric symptoms, is the most prevalent form of dementia among the elderly. Amyloid aggregation, tau hyperphosphorylation, and neural cell loss are the main pathological features. Various hypotheses have been proposed to explain the development of AD. Some therapeutic agents have shown clinical benefits in patients with AD; however, many of these agents have failed. The degree of neural cell loss is associated with the severity of AD. Adult neurogenesis, which governs cognitive and emotional behaviors, occurs in the hippocampus, and some research groups have reported that neural cell transplantation into the hippocampus improves cognitive dysfunction in AD model mice. Based on these clinical findings, stem cell therapy for patients with AD has recently attracted attention. This review provides past and present therapeutic strategies for the management and treatment of AD. Japanese Association for Laboratory Animal Science 2023-03-06 2023 /pmc/articles/PMC10435354/ /pubmed/36878603 http://dx.doi.org/10.1538/expanim.22-0164 Text en ©2023 Japanese Association for Laboratory Animal Science https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial No Derivatives (by-nc-nd) License. (CC-BY-NC-ND 4.0: https://creativecommons.org/licenses/by-nc-nd/4.0/)
spellingShingle Review
Murayama, Masanori A.
The past and present of therapeutic strategy for Alzheimer’s diseases: potential for stem cell therapy
title The past and present of therapeutic strategy for Alzheimer’s diseases: potential for stem cell therapy
title_full The past and present of therapeutic strategy for Alzheimer’s diseases: potential for stem cell therapy
title_fullStr The past and present of therapeutic strategy for Alzheimer’s diseases: potential for stem cell therapy
title_full_unstemmed The past and present of therapeutic strategy for Alzheimer’s diseases: potential for stem cell therapy
title_short The past and present of therapeutic strategy for Alzheimer’s diseases: potential for stem cell therapy
title_sort past and present of therapeutic strategy for alzheimer’s diseases: potential for stem cell therapy
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10435354/
https://www.ncbi.nlm.nih.gov/pubmed/36878603
http://dx.doi.org/10.1538/expanim.22-0164
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