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The past and present of therapeutic strategy for Alzheimer’s diseases: potential for stem cell therapy
Alzheimer’s disease (AD), a progressive neurodegenerative disease characterized by cognitive dysfunction and neuropsychiatric symptoms, is the most prevalent form of dementia among the elderly. Amyloid aggregation, tau hyperphosphorylation, and neural cell loss are the main pathological features. Va...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Japanese Association for Laboratory Animal Science
2023
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10435354/ https://www.ncbi.nlm.nih.gov/pubmed/36878603 http://dx.doi.org/10.1538/expanim.22-0164 |
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author | Murayama, Masanori A. |
author_facet | Murayama, Masanori A. |
author_sort | Murayama, Masanori A. |
collection | PubMed |
description | Alzheimer’s disease (AD), a progressive neurodegenerative disease characterized by cognitive dysfunction and neuropsychiatric symptoms, is the most prevalent form of dementia among the elderly. Amyloid aggregation, tau hyperphosphorylation, and neural cell loss are the main pathological features. Various hypotheses have been proposed to explain the development of AD. Some therapeutic agents have shown clinical benefits in patients with AD; however, many of these agents have failed. The degree of neural cell loss is associated with the severity of AD. Adult neurogenesis, which governs cognitive and emotional behaviors, occurs in the hippocampus, and some research groups have reported that neural cell transplantation into the hippocampus improves cognitive dysfunction in AD model mice. Based on these clinical findings, stem cell therapy for patients with AD has recently attracted attention. This review provides past and present therapeutic strategies for the management and treatment of AD. |
format | Online Article Text |
id | pubmed-10435354 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Japanese Association for Laboratory Animal Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-104353542023-08-19 The past and present of therapeutic strategy for Alzheimer’s diseases: potential for stem cell therapy Murayama, Masanori A. Exp Anim Review Alzheimer’s disease (AD), a progressive neurodegenerative disease characterized by cognitive dysfunction and neuropsychiatric symptoms, is the most prevalent form of dementia among the elderly. Amyloid aggregation, tau hyperphosphorylation, and neural cell loss are the main pathological features. Various hypotheses have been proposed to explain the development of AD. Some therapeutic agents have shown clinical benefits in patients with AD; however, many of these agents have failed. The degree of neural cell loss is associated with the severity of AD. Adult neurogenesis, which governs cognitive and emotional behaviors, occurs in the hippocampus, and some research groups have reported that neural cell transplantation into the hippocampus improves cognitive dysfunction in AD model mice. Based on these clinical findings, stem cell therapy for patients with AD has recently attracted attention. This review provides past and present therapeutic strategies for the management and treatment of AD. Japanese Association for Laboratory Animal Science 2023-03-06 2023 /pmc/articles/PMC10435354/ /pubmed/36878603 http://dx.doi.org/10.1538/expanim.22-0164 Text en ©2023 Japanese Association for Laboratory Animal Science https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial No Derivatives (by-nc-nd) License. (CC-BY-NC-ND 4.0: https://creativecommons.org/licenses/by-nc-nd/4.0/) |
spellingShingle | Review Murayama, Masanori A. The past and present of therapeutic strategy for Alzheimer’s diseases: potential for stem cell therapy |
title | The past and present of therapeutic strategy for Alzheimer’s diseases: potential for stem cell therapy |
title_full | The past and present of therapeutic strategy for Alzheimer’s diseases: potential for stem cell therapy |
title_fullStr | The past and present of therapeutic strategy for Alzheimer’s diseases: potential for stem cell therapy |
title_full_unstemmed | The past and present of therapeutic strategy for Alzheimer’s diseases: potential for stem cell therapy |
title_short | The past and present of therapeutic strategy for Alzheimer’s diseases: potential for stem cell therapy |
title_sort | past and present of therapeutic strategy for alzheimer’s diseases: potential for stem cell therapy |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10435354/ https://www.ncbi.nlm.nih.gov/pubmed/36878603 http://dx.doi.org/10.1538/expanim.22-0164 |
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