Fancm has dual roles in the limiting of meiotic crossovers and germ cell maintenance in mammals

Meiotic crossovers are required for accurate chromosome segregation and producing new allelic combinations. Meiotic crossover numbers are tightly regulated within a narrow range, despite an excess of initiating DNA double-strand breaks. Here, we reveal the tumor suppressor FANCM as a meiotic anti-cr...

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Detalles Bibliográficos
Autores principales: Tsui, Vanessa, Lyu, Ruqian, Novakovic, Stevan, Stringer, Jessica M., Dunleavy, Jessica E.M., Granger, Elissah, Semple, Tim, Leichter, Anna, Martelotto, Luciano G., Merriner, D. Jo, Liu, Ruijie, McNeill, Lucy, Zerafa, Nadeen, Hoffmann, Eva R., O’Bryan, Moira K., Hutt, Karla, Deans, Andrew J., Heierhorst, Jörg, McCarthy, Davis J., Crismani, Wayne
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10435384/
https://www.ncbi.nlm.nih.gov/pubmed/37601968
http://dx.doi.org/10.1016/j.xgen.2023.100349

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