CRISPR screen identifies the role of RBBP8 in mediating unfolded protein response induced liver damage through regulating protein synthesis

Unfolded protein response (UPR) maintains the endoplasmic reticulum (ER) homeostasis, survival, and physiological function of mammalian cells. However, how cells adapt to ER stress under physiological or disease settings remains largely unclear. Here by a genome-wide CRISPR screen, we identified tha...

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Detalles Bibliográficos
Autores principales: Wang, Heting, Pan, Xuya, Xiang, Xiaoxin, Zhang, Yang, Chen, Jianning, Wen, Shiyi, Wang, Jin, Gao, Rong, Yang, Jifeng, Zhi, Yaping, Wen, Siying, Zheng, Yubao, Li, Ting, Ai, Heying, He, Xuemin, Lu, Yan, Zhu, Yanhua, Li, Chunliang, Chen, Yanming, Shi, Guojun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10435451/
https://www.ncbi.nlm.nih.gov/pubmed/37591836
http://dx.doi.org/10.1038/s41419-023-06046-x

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