Ligand recognition and G protein coupling of the human itch receptor MRGPRX1

MRGPRX1, a Mas-related GPCR (MRGPR), is a key receptor for itch perception and targeting MRGPRX1 may have potential to treat both chronic itch and pain. Here we report cryo-EM structures of the MRGPRX1-Gi1 and MRGPRX1-Gq trimers in complex with two peptide ligands, BAM8-22 and CNF-Tx2. These structu...

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Detalles Bibliográficos
Autores principales: Guo, Lulu, Zhang, Yumu, Fang, Guoxing, Tie, Lu, Zhuang, Yuming, Xue, Chenyang, Liu, Qi, Zhang, Minghui, Zhu, Kongkai, You, Chongzhao, Xu, Peiyu, Yuan, Qingning, Zhang, Chao, Liu, Lei, Rong, Naikang, Peng, Shengxuan, Liu, Yuan, Wang, Chuanzheng, Luo, Xin, Lv, Zongyao, Kang, Dongwei, Yu, Xiao, Zhang, Cheng, Jiang, Yi, Dong, Xinzhong, Zhou, Jiuyao, Liu, Zhongmin, Yang, Fan, Eric Xu, H., Sun, Jin-Peng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10435460/
https://www.ncbi.nlm.nih.gov/pubmed/37591889
http://dx.doi.org/10.1038/s41467-023-40705-z

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