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Randomized, double-blind, placebo-controlled trial of rapamycin in amyotrophic lateral sclerosis

In preclinical studies rapamycin was found to target neuroinflammation, by expanding regulatory T cells, and affecting autophagy, two pillars of amyotrophic lateral sclerosis (ALS) pathogenesis. Herein we report a multicenter, randomized, double-blind trial, in 63 ALS patients who were randomly assi...

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Detalles Bibliográficos
Autores principales:	Mandrioli, Jessica, D’Amico, Roberto, Zucchi, Elisabetta, De Biasi, Sara, Banchelli, Federico, Martinelli, Ilaria, Simonini, Cecilia, Lo Tartaro, Domenico, Vicini, Roberto, Fini, Nicola, Gianferrari, Giulia, Pinti, Marcello, Lunetta, Christian, Gerardi, Francesca, Tarlarini, Claudia, Mazzini, Letizia, De Marchi, Fabiola, Scognamiglio, Ada, Sorarù, Gianni, Fortuna, Andrea, Lauria, Giuseppe, Bella, Eleonora Dalla, Caponnetto, Claudia, Meo, Giuseppe, Chio, Adriano, Calvo, Andrea, Cossarizza, Andrea
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10435464/ https://www.ncbi.nlm.nih.gov/pubmed/37591957 http://dx.doi.org/10.1038/s41467-023-40734-8

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