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Bile acids modulate reinstatement of cocaine conditioned place preference and accumbal dopamine dynamics without compromising appetitive learning

Psychostimulants target the dopamine transporter (DAT) to elicit their psychomotor actions. Bile acids (BAs) can also bind to DAT and reduce behavioral responses to cocaine, suggesting a potential therapeutic application of BAs in psychostimulant use disorder. Here, we investigate the potential of B...

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Detalles Bibliográficos
Autores principales: Zanella, Daniele, Smith, Nicholas K., Hardaway, J. Andrew, Buchanan, Anna Marie, Mullins, Clarence H., Galli, Aurelio, Carter, Angela M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10435481/
https://www.ncbi.nlm.nih.gov/pubmed/37591972
http://dx.doi.org/10.1038/s41598-023-40456-3