Resolving the spatial architecture of myeloma and its microenvironment at the single-cell level

In multiple myeloma spatial differences in the subclonal architecture, molecular signatures and composition of the microenvironment remain poorly characterized. To address this shortcoming, we perform multi-region sequencing on paired random bone marrow and focal lesion samples from 17 newly diagnos...

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Detalles Bibliográficos
Autores principales: John, Lukas, Poos, Alexandra M., Brobeil, Alexander, Schinke, Carolina, Huhn, Stefanie, Prokoph, Nina, Lutz, Raphael, Wagner, Barbara, Zangari, Maurizio, Tirier, Stephan M., Mallm, Jan-Philipp, Schumacher, Sabrina, Vonficht, Dominik, Solé-Boldo, Llorenç, Quick, Sabine, Steiger, Simon, Przybilla, Moritz J., Bauer, Katharina, Baumann, Anja, Hemmer, Stefan, Rehnitz, Christoph, Lückerath, Christian, Sachpekidis, Christos, Mechtersheimer, Gunhild, Haberkorn, Uwe, Dimitrakopoulou-Strauss, Antonia, Reichert, Philipp, Barlogie, Bart, Müller-Tidow, Carsten, Goldschmidt, Hartmut, Hillengass, Jens, Rasche, Leo, Haas, Simon F., van Rhee, Frits, Rippe, Karsten, Raab, Marc S., Sauer, Sandra, Weinhold, Niels
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10435504/
https://www.ncbi.nlm.nih.gov/pubmed/37591845
http://dx.doi.org/10.1038/s41467-023-40584-4

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