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Molecular insights into recognition of GUCY2C by T-cell engaging bispecific antibody anti-GUCY2CxCD3

The intestinal epithelial receptor Guanylyl Cyclase C (GUCY2C) is a tumor-associated cell surface antigen expressed across gastrointestinal malignancies that can serve as an efficacious target for colorectal cancer immunotherapy. Here, we describe a yeast surface-display approach combined with an or...

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Detalles Bibliográficos
Autores principales:	Rampuria, Pragya, Mosyak, Lidia, Root, Adam R., Svenson, Kristine, Agostino, Michael J., LaVallie, Edward R.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10435522/ https://www.ncbi.nlm.nih.gov/pubmed/37591971 http://dx.doi.org/10.1038/s41598-023-40467-0

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