Levels of inflammatory markers are differentially expressed in sickle cell anemia and sickle cell trait

Although sickle cell anemia (SCA) is related to inflammation, the profile of inflammatory markers in sickle cell trait (SCT) is poorly studied. This is a cross‐sectional study of inflammatory biomarkers carried out involving adults with SCA in steady state, SCT and controls. The SCA group had higher...

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Detalles Bibliográficos
Autores principales: Gomes, Ingrid Cristiane Pereira, Magalhães, Lucas Sousa, Bomfim, Lays Gisele Santos, dos Santos, Priscila Lima, Silva, Roberto Jerônimo dos Santos, Cruz, Maria Carollyne Passos, de Albuquerque, Lindemberg Costa, Neves, Victoria Haydée Deusdedith, de Oliveira, Paula Gabriella Pereira Rosa, Carvalho, Alessandro Freire, Silva, Lucas Oliveira, Aragão, Matheus Todt, Moura, Tatiana Rodrigues, Cipolotti, Rosana
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2023
Materias:
Short Reports
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10435695/
https://www.ncbi.nlm.nih.gov/pubmed/37601842
http://dx.doi.org/10.1002/jha2.712
Descripción
Sumario:Although sickle cell anemia (SCA) is related to inflammation, the profile of inflammatory markers in sickle cell trait (SCT) is poorly studied. This is a cross‐sectional study of inflammatory biomarkers carried out involving adults with SCA in steady state, SCT and controls. The SCA group had higher levels of lactato dehydrogenase, IL‐1β, IL‐6, IL‐10, and tumor necrosis factor alpha than the others, while the SCT group had similar levels to control group. In addition, SCA group had lower IL‐8/IL‐10 and soluble triggering receptor expressed on myeloid cells‐1/IL‐10 ratios. These findings indicate that individuals with SCT do not have a chronic inflammatory profile and reinforce that cytokines are involved in the maintenance of the inflammatory state in SCA.

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